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Human DNA polymerase θ grasps the primer terminus to mediate DNA repair

DNA polymerase θ protects against genomic instability via an alternative end-joining repair pathway for DNA double-strand breaks. Breast, lung and oral cancers over-express polymerase θ, and reduction of its activity in mammalian cells increases sensitivity to double-strand break inducing agents, in...

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Detalles Bibliográficos
Autores principales:	Zahn, Karl E., Averill, April M., Aller, Pierre, Wood, Richard D., Doublié, Sylvie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385486/ https://www.ncbi.nlm.nih.gov/pubmed/25775267 http://dx.doi.org/10.1038/nsmb.2993

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