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Hidden Metabolic Disturbances in Women with Normal Glucose Tolerance Five Years after Gestational Diabetes

Background. The study aimed to assess whether women with prior gestational diabetes (pGDM), despite maintenance of normal glucose tolerance (NGT) five years after delivery, display metabolic disturbances compared to healthy controls. Methods. 45 pGDM with NGT were compared to 18 women without a hist...

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Autores principales: Winhofer, Yvonne, Tura, Andrea, Thomas, Anita, Prikoszovich, Thomas, Winzer, Christine, Pacini, Giovanni, Luger, Anton, Kautzky-Willer, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385652/
https://www.ncbi.nlm.nih.gov/pubmed/25873951
http://dx.doi.org/10.1155/2015/342938
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author Winhofer, Yvonne
Tura, Andrea
Thomas, Anita
Prikoszovich, Thomas
Winzer, Christine
Pacini, Giovanni
Luger, Anton
Kautzky-Willer, Alexandra
author_facet Winhofer, Yvonne
Tura, Andrea
Thomas, Anita
Prikoszovich, Thomas
Winzer, Christine
Pacini, Giovanni
Luger, Anton
Kautzky-Willer, Alexandra
author_sort Winhofer, Yvonne
collection PubMed
description Background. The study aimed to assess whether women with prior gestational diabetes (pGDM), despite maintenance of normal glucose tolerance (NGT) five years after delivery, display metabolic disturbances compared to healthy controls. Methods. 45 pGDM with NGT were compared to 18 women without a history of GDM (CON), matched for age (37.0 ± 4.1 versus 35.2 ± 5.3, P = ns) and BMI (24.3 ± 3.1 versus 23.3 ± 3.3, P = ns). Metabolic parameters were derived from oral and intravenous glucose tolerance tests; furthermore lipid profile, C-reactive protein (CRP), adiponectin, leptin, and glucagon were assessed. Results. Five years postpartum, pGDM had increased glucose concentrations during the OGTT (AUC: 1.12 ± 0.15 versus 1.0 ± 0.12 mol/L ∗ min, P = 0.003) and insulin sensitivity was decreased compared to CON (OGIS: 467.2 ± 64.1 versus 510.6 ± 53.1 mL/min ∗ m(2), P = 0.01). pGDM had lower adiponectin (8.1 ± 2.6 versus 12.6 ± 5.3, P < 0.008) but increased waist circumference and CRP compared to CON. Conclusions. Despite diagnosis of normal glucose tolerance, pGDM are characterized by hyperglycemia and insulin resistance compared to healthy controls, accompanied by decreased adiponectin and increased CRP concentrations, thus linking metabolic disturbances to an increased cardiovascular risk in pGDM.
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spelling pubmed-43856522015-04-13 Hidden Metabolic Disturbances in Women with Normal Glucose Tolerance Five Years after Gestational Diabetes Winhofer, Yvonne Tura, Andrea Thomas, Anita Prikoszovich, Thomas Winzer, Christine Pacini, Giovanni Luger, Anton Kautzky-Willer, Alexandra Int J Endocrinol Research Article Background. The study aimed to assess whether women with prior gestational diabetes (pGDM), despite maintenance of normal glucose tolerance (NGT) five years after delivery, display metabolic disturbances compared to healthy controls. Methods. 45 pGDM with NGT were compared to 18 women without a history of GDM (CON), matched for age (37.0 ± 4.1 versus 35.2 ± 5.3, P = ns) and BMI (24.3 ± 3.1 versus 23.3 ± 3.3, P = ns). Metabolic parameters were derived from oral and intravenous glucose tolerance tests; furthermore lipid profile, C-reactive protein (CRP), adiponectin, leptin, and glucagon were assessed. Results. Five years postpartum, pGDM had increased glucose concentrations during the OGTT (AUC: 1.12 ± 0.15 versus 1.0 ± 0.12 mol/L ∗ min, P = 0.003) and insulin sensitivity was decreased compared to CON (OGIS: 467.2 ± 64.1 versus 510.6 ± 53.1 mL/min ∗ m(2), P = 0.01). pGDM had lower adiponectin (8.1 ± 2.6 versus 12.6 ± 5.3, P < 0.008) but increased waist circumference and CRP compared to CON. Conclusions. Despite diagnosis of normal glucose tolerance, pGDM are characterized by hyperglycemia and insulin resistance compared to healthy controls, accompanied by decreased adiponectin and increased CRP concentrations, thus linking metabolic disturbances to an increased cardiovascular risk in pGDM. Hindawi Publishing Corporation 2015 2015-03-22 /pmc/articles/PMC4385652/ /pubmed/25873951 http://dx.doi.org/10.1155/2015/342938 Text en Copyright © 2015 Yvonne Winhofer et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Winhofer, Yvonne
Tura, Andrea
Thomas, Anita
Prikoszovich, Thomas
Winzer, Christine
Pacini, Giovanni
Luger, Anton
Kautzky-Willer, Alexandra
Hidden Metabolic Disturbances in Women with Normal Glucose Tolerance Five Years after Gestational Diabetes
title Hidden Metabolic Disturbances in Women with Normal Glucose Tolerance Five Years after Gestational Diabetes
title_full Hidden Metabolic Disturbances in Women with Normal Glucose Tolerance Five Years after Gestational Diabetes
title_fullStr Hidden Metabolic Disturbances in Women with Normal Glucose Tolerance Five Years after Gestational Diabetes
title_full_unstemmed Hidden Metabolic Disturbances in Women with Normal Glucose Tolerance Five Years after Gestational Diabetes
title_short Hidden Metabolic Disturbances in Women with Normal Glucose Tolerance Five Years after Gestational Diabetes
title_sort hidden metabolic disturbances in women with normal glucose tolerance five years after gestational diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385652/
https://www.ncbi.nlm.nih.gov/pubmed/25873951
http://dx.doi.org/10.1155/2015/342938
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