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Antigenic Heterogeneity in Granular Cell Ameloblastoma: An Immunohistochemical Study
BACKGROUND: Nature of granular cells in granular cell ameloblastoma (GCA) has always invoked considerable interest. The present study aims at antigenic characterization in five such cases with a panel of markers. MATERIALS AND METHODS: Tissue specimens of five patients with GCA were fixed in buffere...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dentmedpub Research and Printing Co
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385726/ https://www.ncbi.nlm.nih.gov/pubmed/25878479 |
Sumario: | BACKGROUND: Nature of granular cells in granular cell ameloblastoma (GCA) has always invoked considerable interest. The present study aims at antigenic characterization in five such cases with a panel of markers. MATERIALS AND METHODS: Tissue specimens of five patients with GCA were fixed in buffered formalin and later embedded in paraffin wax. Blocks were sliced into 3 µ thick sections for immunohistochemical analysis using a panel of markers CD68, Bcl2, S100, p53, cytokeratin (AE1/AE3), vimentin and desmin. RESULTS: All five cases were strongly positive for cytokeratin and CD68. S100 was negative in three cases and showed a mild positivity in two cases. Bcl2, p53, vimentin and desmin were negative in all the five cases. CONCLUSIONS: This study presents a heterogenous nature of the granular cells; however, further validation is required with a larger sample size. |
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