An Adjuvanted, Tetravalent Dengue Virus Purified Inactivated Vaccine Candidate Induces Long-Lasting and Protective Antibody Responses Against Dengue Challenge in Rhesus Macaques

The immunogenicity and protective efficacy of a candidate tetravalent dengue virus purified inactivated vaccine (TDENV PIV) formulated with alum or an Adjuvant System (AS01, AS03 tested at three different dose levels, or AS04) was evaluated in a 0, 1-month vaccination schedule in rhesus macaques. On...

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Autores principales: Fernandez, Stefan, Thomas, Stephen J., De La Barrera, Rafael, Im-erbsin, Rawiwan, Jarman, Richard G., Baras, Benoît, Toussaint, Jean-François, Mossman, Sally, Innis, Bruce L., Schmidt, Alexander, Malice, Marie-Pierre, Festraets, Pascale, Warter, Lucile, Putnak, J. Robert, Eckels, Kenneth H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385761/
https://www.ncbi.nlm.nih.gov/pubmed/25646261
http://dx.doi.org/10.4269/ajtmh.14-0268
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author Fernandez, Stefan
Thomas, Stephen J.
De La Barrera, Rafael
Im-erbsin, Rawiwan
Jarman, Richard G.
Baras, Benoît
Toussaint, Jean-François
Mossman, Sally
Innis, Bruce L.
Schmidt, Alexander
Malice, Marie-Pierre
Festraets, Pascale
Warter, Lucile
Putnak, J. Robert
Eckels, Kenneth H.
author_facet Fernandez, Stefan
Thomas, Stephen J.
De La Barrera, Rafael
Im-erbsin, Rawiwan
Jarman, Richard G.
Baras, Benoît
Toussaint, Jean-François
Mossman, Sally
Innis, Bruce L.
Schmidt, Alexander
Malice, Marie-Pierre
Festraets, Pascale
Warter, Lucile
Putnak, J. Robert
Eckels, Kenneth H.
author_sort Fernandez, Stefan
collection PubMed
description The immunogenicity and protective efficacy of a candidate tetravalent dengue virus purified inactivated vaccine (TDENV PIV) formulated with alum or an Adjuvant System (AS01, AS03 tested at three different dose levels, or AS04) was evaluated in a 0, 1-month vaccination schedule in rhesus macaques. One month after dose 2, all adjuvanted formulations elicited robust and persisting neutralizing antibody titers against all four dengue virus serotypes. Most of the formulations tested prevented viremia after challenge, with the dengue serotype 1 and 2 virus strains administered at 40 and 32 weeks post-dose 2, respectively. This study shows that inactivated dengue vaccines, when formulated with alum or an Adjuvant System, are candidates for further development.
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spelling pubmed-43857612015-04-16 An Adjuvanted, Tetravalent Dengue Virus Purified Inactivated Vaccine Candidate Induces Long-Lasting and Protective Antibody Responses Against Dengue Challenge in Rhesus Macaques Fernandez, Stefan Thomas, Stephen J. De La Barrera, Rafael Im-erbsin, Rawiwan Jarman, Richard G. Baras, Benoît Toussaint, Jean-François Mossman, Sally Innis, Bruce L. Schmidt, Alexander Malice, Marie-Pierre Festraets, Pascale Warter, Lucile Putnak, J. Robert Eckels, Kenneth H. Am J Trop Med Hyg Articles The immunogenicity and protective efficacy of a candidate tetravalent dengue virus purified inactivated vaccine (TDENV PIV) formulated with alum or an Adjuvant System (AS01, AS03 tested at three different dose levels, or AS04) was evaluated in a 0, 1-month vaccination schedule in rhesus macaques. One month after dose 2, all adjuvanted formulations elicited robust and persisting neutralizing antibody titers against all four dengue virus serotypes. Most of the formulations tested prevented viremia after challenge, with the dengue serotype 1 and 2 virus strains administered at 40 and 32 weeks post-dose 2, respectively. This study shows that inactivated dengue vaccines, when formulated with alum or an Adjuvant System, are candidates for further development. The American Society of Tropical Medicine and Hygiene 2015-04-01 /pmc/articles/PMC4385761/ /pubmed/25646261 http://dx.doi.org/10.4269/ajtmh.14-0268 Text en ©The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Articles
Fernandez, Stefan
Thomas, Stephen J.
De La Barrera, Rafael
Im-erbsin, Rawiwan
Jarman, Richard G.
Baras, Benoît
Toussaint, Jean-François
Mossman, Sally
Innis, Bruce L.
Schmidt, Alexander
Malice, Marie-Pierre
Festraets, Pascale
Warter, Lucile
Putnak, J. Robert
Eckels, Kenneth H.
An Adjuvanted, Tetravalent Dengue Virus Purified Inactivated Vaccine Candidate Induces Long-Lasting and Protective Antibody Responses Against Dengue Challenge in Rhesus Macaques
title An Adjuvanted, Tetravalent Dengue Virus Purified Inactivated Vaccine Candidate Induces Long-Lasting and Protective Antibody Responses Against Dengue Challenge in Rhesus Macaques
title_full An Adjuvanted, Tetravalent Dengue Virus Purified Inactivated Vaccine Candidate Induces Long-Lasting and Protective Antibody Responses Against Dengue Challenge in Rhesus Macaques
title_fullStr An Adjuvanted, Tetravalent Dengue Virus Purified Inactivated Vaccine Candidate Induces Long-Lasting and Protective Antibody Responses Against Dengue Challenge in Rhesus Macaques
title_full_unstemmed An Adjuvanted, Tetravalent Dengue Virus Purified Inactivated Vaccine Candidate Induces Long-Lasting and Protective Antibody Responses Against Dengue Challenge in Rhesus Macaques
title_short An Adjuvanted, Tetravalent Dengue Virus Purified Inactivated Vaccine Candidate Induces Long-Lasting and Protective Antibody Responses Against Dengue Challenge in Rhesus Macaques
title_sort adjuvanted, tetravalent dengue virus purified inactivated vaccine candidate induces long-lasting and protective antibody responses against dengue challenge in rhesus macaques
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385761/
https://www.ncbi.nlm.nih.gov/pubmed/25646261
http://dx.doi.org/10.4269/ajtmh.14-0268
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