Functional repair of p53 mutation in colorectal cancer cells using trans-splicing

Mutation in the p53 gene is arguably the most frequent type of gene-specific alterations in human cancers. Current p53-based gene therapy contains the administration of wt-p53 or the suppression of mutant p53 expression in p53-defective cancer cells. We hypothesized that trans-splicing could be expl...

Descripción completa

Detalles Bibliográficos
Autores principales: He, Xingxing, Liao, Jiazhi, Liu, Fang, Yan, Junwei, Yan, Jingjun, Shang, Haitao, Dou, Qian, Chang, Ying, Lin, Jusheng, Song, Yuhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385834/
https://www.ncbi.nlm.nih.gov/pubmed/25576916

Ejemplares similares

Ejemplares similares