The anti-leukemic activity of sodium dichloroacetate in p53(mutated/null) cells is mediated by a p53-independent ILF3/p21 pathway

B-chronic lymphocytic leukemia (B-CLL) patients harboring p53 mutations are invariably refractory to therapies based on purine analogues and have limited treatment options and poor survival. Having recently demonstrated that the mitochondria-targeting small molecule sodium dichloroacetate (DCA) exhi...

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Detalles Bibliográficos
Autores principales: Agnoletto, Chiara, Brunelli, Laura, Melloni, Elisabetta, Pastorelli, Roberta, Casciano, Fabio, Rimondi, Erika, Rigolin, Gian Matteo, Cuneo, Antonio, Secchiero, Paola, Zauli, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385858/
https://www.ncbi.nlm.nih.gov/pubmed/25544776

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