Bax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases

Ku70 (Lupus Ku autoantigen p70) is essential in nonhomologous end joining DNA double-strand break repair, and ku70(−/−) mice age prematurely because of increased genomic instability and DNA damage responses. Previously, we found that Ku70 also inhibits Bax, a key mediator of apoptosis. We hypothesiz...

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Detalles Bibliográficos
Autores principales: Ngo, J, Matsuyama, M, Kim, C, Poventud-Fuentes, I, Bates, A, Siedlak, S L, Lee, H-g, Doughman, Y Q, Watanabe, M, Liner, A, Hoit, B, Voelkel, N, Gerson, S, Hasty, P, Matsuyama, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385910/
https://www.ncbi.nlm.nih.gov/pubmed/25811803
http://dx.doi.org/10.1038/cddis.2015.11

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385910/
https://www.ncbi.nlm.nih.gov/pubmed/25811803
http://dx.doi.org/10.1038/cddis.2015.11

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