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Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover

Increasing amounts of evidence strongly suggests that dysregulation of ubiquitin-proteasome system is closely associated with cancer pathogenesis. Speckle-type POZ protein (SPOP) is an adapter protein of the CUL3-based E3 ubiquitin ligase complexes. It selectively recruits substrates for their ubiqu...

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Detalles Bibliográficos
Autores principales:	Zhang, P, Gao, K, Jin, X, Ma, J, Peng, J, Wumaier, R, Tang, Y, Zhang, Y, An, J, Yan, Q, Dong, Y, Huang, H, Yu, L, Wang, C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385925/ https://www.ncbi.nlm.nih.gov/pubmed/25766326 http://dx.doi.org/10.1038/cddis.2015.47

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