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IGFBP-rP1 suppresses epithelial–mesenchymal transition and metastasis in colorectal cancer
Epithelial–mesenchymal transition (EMT) was initially recognized during organogenesis and has recently been reported to be involved in promoting cancer invasion and metastasis. Cooperation of transforming growth factor-β (TGF-β) and other signaling pathways, such as Ras and Wnt, is essential to indu...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385937/ https://www.ncbi.nlm.nih.gov/pubmed/25789970 http://dx.doi.org/10.1038/cddis.2015.59 |
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author | Zhu, S Zhang, J Xu, F Xu, E Ruan, W Ma, Y Huang, Q Lai, M |
author_facet | Zhu, S Zhang, J Xu, F Xu, E Ruan, W Ma, Y Huang, Q Lai, M |
author_sort | Zhu, S |
collection | PubMed |
description | Epithelial–mesenchymal transition (EMT) was initially recognized during organogenesis and has recently been reported to be involved in promoting cancer invasion and metastasis. Cooperation of transforming growth factor-β (TGF-β) and other signaling pathways, such as Ras and Wnt, is essential to inducing EMT, but the molecular mechanisms remain to be fully determined. Here, we reported that insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1), a potential tumor suppressor, controls EMT in colorectal cancer progression. We revealed the inhibitory role of IGFBP-rP1 through analyses of clinical colorectal cancer samples and various EMT and metastasis models in vitro and in vivo. Moreover, we demonstrated that IGFBP-rP1 suppresses EMT and tumor metastasis by repressing TGF-β-mediated EMT through the Smad signaling cascade. These data establish that IGFBP-rP1 functions as a suppressor of EMT and metastasis in colorectal cancer. |
format | Online Article Text |
id | pubmed-4385937 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-43859372015-04-07 IGFBP-rP1 suppresses epithelial–mesenchymal transition and metastasis in colorectal cancer Zhu, S Zhang, J Xu, F Xu, E Ruan, W Ma, Y Huang, Q Lai, M Cell Death Dis Original Article Epithelial–mesenchymal transition (EMT) was initially recognized during organogenesis and has recently been reported to be involved in promoting cancer invasion and metastasis. Cooperation of transforming growth factor-β (TGF-β) and other signaling pathways, such as Ras and Wnt, is essential to inducing EMT, but the molecular mechanisms remain to be fully determined. Here, we reported that insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1), a potential tumor suppressor, controls EMT in colorectal cancer progression. We revealed the inhibitory role of IGFBP-rP1 through analyses of clinical colorectal cancer samples and various EMT and metastasis models in vitro and in vivo. Moreover, we demonstrated that IGFBP-rP1 suppresses EMT and tumor metastasis by repressing TGF-β-mediated EMT through the Smad signaling cascade. These data establish that IGFBP-rP1 functions as a suppressor of EMT and metastasis in colorectal cancer. Nature Publishing Group 2015-03 2015-03-19 /pmc/articles/PMC4385937/ /pubmed/25789970 http://dx.doi.org/10.1038/cddis.2015.59 Text en Copyright © 2015 Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0 |
spellingShingle | Original Article Zhu, S Zhang, J Xu, F Xu, E Ruan, W Ma, Y Huang, Q Lai, M IGFBP-rP1 suppresses epithelial–mesenchymal transition and metastasis in colorectal cancer |
title | IGFBP-rP1 suppresses epithelial–mesenchymal transition and metastasis in colorectal cancer |
title_full | IGFBP-rP1 suppresses epithelial–mesenchymal transition and metastasis in colorectal cancer |
title_fullStr | IGFBP-rP1 suppresses epithelial–mesenchymal transition and metastasis in colorectal cancer |
title_full_unstemmed | IGFBP-rP1 suppresses epithelial–mesenchymal transition and metastasis in colorectal cancer |
title_short | IGFBP-rP1 suppresses epithelial–mesenchymal transition and metastasis in colorectal cancer |
title_sort | igfbp-rp1 suppresses epithelial–mesenchymal transition and metastasis in colorectal cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385937/ https://www.ncbi.nlm.nih.gov/pubmed/25789970 http://dx.doi.org/10.1038/cddis.2015.59 |
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