Induction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia

Neuroinflammation is a striking hallmark of amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. Previous studies have shown the contribution of glial cells such as astrocytes in TDP-43-linked ALS. However, the role of microglia in TDP-43-mediated motor neuron degeneration rema...

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Detalles Bibliográficos
Autores principales: Xia, Q, Hu, Q, Wang, H, Yang, H, Gao, F, Ren, H, Chen, D, Fu, C, Zheng, L, Zhen, X, Ying, Z, Wang, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385945/
https://www.ncbi.nlm.nih.gov/pubmed/25811799
http://dx.doi.org/10.1038/cddis.2015.69

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