Cargando…

Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice

Fibroblast growth factor (FGF) 21 is an endocrine factor that normalizes glucose homeostasis and reduces insulin resistance in diabetes. Although the pancreas is an FGF21 target organ, its role in pancreatic islets remains obscure. This study aimed to elucidate the physiological role of FGF21 in pan...

Descripción completa

Detalles Bibliográficos
Autores principales:	So, W Y, Cheng, Q, Xu, A, Lam, K S L, Leung, P S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385948/ https://www.ncbi.nlm.nih.gov/pubmed/25811804 http://dx.doi.org/10.1038/cddis.2015.80

Ejemplares similares

High Glucose Represses β-Klotho Expression and Impairs Fibroblast Growth Factor 21 Action in Mouse Pancreatic Islets: Involvement of Peroxisome Proliferator–Activated Receptor γ Signaling
por: So, Wing Yan, et al.
Publicado: (2013)

The Potential Protective Action of Vitamin D in Hepatic Insulin Resistance and Pancreatic Islet Dysfunction in Type 2 Diabetes Mellitus
por: Leung, Po Sing
Publicado: (2016)

Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas
por: Singhal, Garima, et al.
Publicado: (2016)

Fibroblast Growth Factor 21 Stimulates Pancreatic Islet Autophagy via Inhibition of AMPK-mTOR Signaling
por: Cheng, Sam Tsz Wai, et al.
Publicado: (2019)

Alcohol ingestion induces pancreatic islet dysfunction and apoptosis via mediation of FGF21 resistance
por: Yang, Bao Chen, et al.
Publicado: (2020)

Respiratory Parameters for the Classification of Dysfunctional Insulin Secretion by Pancreatic Islets
por: Kabra, Uma D., et al.
Publicado: (2021)

Amiloride derivatives enhance insulin release in pancreatic islets from diabetic mice
por: Gunawardana, Subhadra C, et al.
Publicado: (2005)

Nonclassical Islet Peptides: Pancreatic and Extrapancreatic Actions
por: English, Andrew, et al.
Publicado: (2019)

Fibroblast Growth Factor 21 Action in the Brain Increases Energy Expenditure and Insulin Sensitivity in Obese Rats
por: Sarruf, David A., et al.
Publicado: (2010)

Islet cell dysfunction in patients with chronic pancreatitis
por: Roy, Ayan, et al.
Publicado: (2020)

The loss of pancreatic islet NADPH oxidase (NOX)2 improves islet transplantation
por: Wrublewsky, Selina, et al.
Publicado: (2022)

Stanniocalcin-1 Co-Localizes with Insulin in the Pancreatic Islets
por: Zaidi, Deenaz, et al.
Publicado: (2012)

Zinc in Pancreatic Islet Biology, Insulin Sensitivity, and Diabetes
por: Maret, Wolfgang
Publicado: (2017)

Exercise Increases Insulin Content and Basal Secretion in Pancreatic Islets in Type 1 Diabetic Mice
por: Huang, Han-Hung, et al.
Publicado: (2011)

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions
por: Habegger, Kirk M., et al.
Publicado: (2013)

Elevated Fibroblast growth factor 21 (FGF21) in obese, insulin resistant states is normalised by the synthetic retinoid Fenretinide in mice
por: Morrice, Nicola, et al.
Publicado: (2017)

Insulin expression in β cells is reduced within islets before islet loss in diabetic cats
por: Bergomi, V., et al.
Publicado: (2022)

The effect of unhealthy β-cells on insulin secretion in pancreatic islets
por: Pu, Yang, et al.
Publicado: (2013)

Control of Insulin Secretion by Cholinergic Signaling in the Human Pancreatic Islet
por: Molina, Judith, et al.
Publicado: (2014)

Melatonin and Pancreatic Islets: Interrelationships between Melatonin, Insulin and Glucagon
por: Peschke, Elmar, et al.
Publicado: (2013)

Methylamine Activates Glucose Uptake in Human Adipocytes Without Overpassing Action of Insulin or Stimulating its Secretion in Pancreatic Islets
por: Carpéné, Christian, et al.
Publicado: (2019)

Mercuric Compounds Induce Pancreatic Islets Dysfunction and Apoptosis in Vivo
por: Chen, Kuo-Liang, et al.
Publicado: (2012)

Sex differences underlying pancreatic islet biology and its dysfunction
por: Gannon, Maureen, et al.
Publicado: (2018)

Mitochondrial dysfunction and pancreatic islet β-cell failure (Review)
por: Sha, Wenxin, et al.
Publicado: (2020)

Fibroblast growth factor 21 in heart failure
por: Tucker, William, et al.
Publicado: (2022)

Restructuring of Pancreatic Islets and Insulin Secretion in a Postnatal Critical Window
por: Aguayo-Mazzucato, Cristina, et al.
Publicado: (2006)

Pancreatic Islet Vasculature Adapts to Insulin Resistance Through Dilation and Not Angiogenesis
por: Dai, Chunhua, et al.
Publicado: (2013)

Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides
por: Wan, Xiaoxiao, et al.
Publicado: (2018)

Insulin modulates the frequency of Ca(2+) oscillations in mouse pancreatic islets
por: Lee, Boah, et al.
Publicado: (2017)

Effects of Tocotrienols on Insulin Secretion-Associated Genes Expression of Rat Pancreatic Islets in a Dynamic Culture
por: Chia, Ling L., et al.
Publicado: (2016)

Elevated Serum Fibroblast Growth Factor 21 in Humans with Acute Pancreatitis
por: Shenoy, Vivek K., et al.
Publicado: (2016)

Fibroblast growth factor 7 releasing particles enhance islet engraftment and improve metabolic control following islet transplantation in mice with diabetes
por: Alwahsh, Salamah M., et al.
Publicado: (2021)

Ectopic synthesis of epidermal cytokeratins in pancreatic islet cells of transgenic mice interferes with cytoskeletal order and insulin production
Publicado: (1993)

Renin-Angiotensin System Blockers Protect Pancreatic Islets against Diet-Induced Obesity and Insulin Resistance in Mice
por: Frantz, Eliete Dalla Corte, et al.
Publicado: (2013)

Adult muscle-derived stem cells engraft and differentiate into insulin-expressing cells in pancreatic islets of diabetic mice
por: Mitutsova, Violeta, et al.
Publicado: (2017)

Too Much Glucagon, Too Little Insulin: Time course of pancreatic islet dysfunction in new-onset type 1 diabetes
por: Brown, Rebecca J., et al.
Publicado: (2008)

Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis
por: Kwok, Kelvin H. M., et al.
Publicado: (2017)

Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR
por: Guo, Jing Hui, et al.
Publicado: (2014)

Fibroblast Growth Factor 21 (FGF21) Administration Sex-Specifically Affects Blood Insulin Levels and Liver Steatosis in Obese A(y) Mice
por: Makarova, Elena, et al.
Publicado: (2021)

Cytokines Inducing Bone Marrow SCA(+) Cells Migration into Pancreatic Islet and Conversion into Insulin-Positive Cells In Vivo
por: Luo, LuGuang, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_u8ehv59quj5jd6trarll869ajn