Muscle-building supplement use and increased risk of testicular germ cell cancer in men from Connecticut and Massachusetts

BACKGROUND: No analytic epidemiological study has examined the relationship between use of muscle-building supplements (MBSs) and testicular germ cell cancer (TGCC) risk. METHODS: We conducted a population-based case–control study including 356 TGCC cases and 513 controls from Connecticut and Massac...

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Autores principales: Li, N, Hauser, R, Holford, T, Zhu, Y, Zhang, Y, Bassig, B A, Honig, S, Chen, C, Boyle, P, Dai, M, Schwartz, S M, Morey, P, Sayward, H, Hu, Z, Shen, H, Gomery, P, Zheng, T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385953/
https://www.ncbi.nlm.nih.gov/pubmed/25826226
http://dx.doi.org/10.1038/bjc.2015.26
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author Li, N
Hauser, R
Holford, T
Zhu, Y
Zhang, Y
Bassig, B A
Honig, S
Chen, C
Boyle, P
Dai, M
Schwartz, S M
Morey, P
Sayward, H
Hu, Z
Shen, H
Gomery, P
Zheng, T
author_facet Li, N
Hauser, R
Holford, T
Zhu, Y
Zhang, Y
Bassig, B A
Honig, S
Chen, C
Boyle, P
Dai, M
Schwartz, S M
Morey, P
Sayward, H
Hu, Z
Shen, H
Gomery, P
Zheng, T
author_sort Li, N
collection PubMed
description BACKGROUND: No analytic epidemiological study has examined the relationship between use of muscle-building supplements (MBSs) and testicular germ cell cancer (TGCC) risk. METHODS: We conducted a population-based case–control study including 356 TGCC cases and 513 controls from Connecticut and Massachusetts. RESULTS: The odds ratio (OR) for ever use of MBSs in relation to risk of TGCC was significantly elevated (OR=1.65, 95% confidence interval (CI): 1.11–2.46). The associations were significantly stronger among early users, men with more types of MBSs used, and longer periods of use. CONCLUSIONS: MBS use is a potentially modifiable risk factor that may be associated with TGCC.
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spelling pubmed-43859532016-03-31 Muscle-building supplement use and increased risk of testicular germ cell cancer in men from Connecticut and Massachusetts Li, N Hauser, R Holford, T Zhu, Y Zhang, Y Bassig, B A Honig, S Chen, C Boyle, P Dai, M Schwartz, S M Morey, P Sayward, H Hu, Z Shen, H Gomery, P Zheng, T Br J Cancer Epidemiology BACKGROUND: No analytic epidemiological study has examined the relationship between use of muscle-building supplements (MBSs) and testicular germ cell cancer (TGCC) risk. METHODS: We conducted a population-based case–control study including 356 TGCC cases and 513 controls from Connecticut and Massachusetts. RESULTS: The odds ratio (OR) for ever use of MBSs in relation to risk of TGCC was significantly elevated (OR=1.65, 95% confidence interval (CI): 1.11–2.46). The associations were significantly stronger among early users, men with more types of MBSs used, and longer periods of use. CONCLUSIONS: MBS use is a potentially modifiable risk factor that may be associated with TGCC. Nature Publishing Group 2015-03-31 2015-03-31 /pmc/articles/PMC4385953/ /pubmed/25826226 http://dx.doi.org/10.1038/bjc.2015.26 Text en Copyright © 2015 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Epidemiology
Li, N
Hauser, R
Holford, T
Zhu, Y
Zhang, Y
Bassig, B A
Honig, S
Chen, C
Boyle, P
Dai, M
Schwartz, S M
Morey, P
Sayward, H
Hu, Z
Shen, H
Gomery, P
Zheng, T
Muscle-building supplement use and increased risk of testicular germ cell cancer in men from Connecticut and Massachusetts
title Muscle-building supplement use and increased risk of testicular germ cell cancer in men from Connecticut and Massachusetts
title_full Muscle-building supplement use and increased risk of testicular germ cell cancer in men from Connecticut and Massachusetts
title_fullStr Muscle-building supplement use and increased risk of testicular germ cell cancer in men from Connecticut and Massachusetts
title_full_unstemmed Muscle-building supplement use and increased risk of testicular germ cell cancer in men from Connecticut and Massachusetts
title_short Muscle-building supplement use and increased risk of testicular germ cell cancer in men from Connecticut and Massachusetts
title_sort muscle-building supplement use and increased risk of testicular germ cell cancer in men from connecticut and massachusetts
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385953/
https://www.ncbi.nlm.nih.gov/pubmed/25826226
http://dx.doi.org/10.1038/bjc.2015.26
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