A distinct pre-existing inflammatory tumour microenvironment is associated with chemotherapy resistance in high-grade serous epithelial ovarian cancer

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BACKGROUND: Chemotherapy resistance is a major determinant of poor overall survival rates in high-grade serous ovarian cancer (HGSC). We have previously shown that gene expression alterations affecting the NF-κB pathway characterise chemotherapy resistance in HGSC, suggesting that the regulation of...

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Detalles Bibliográficos
Autores principales: Koti, M, Siu, A, Clément, I, Bidarimath, M, Turashvili, G, Edwards, A, Rahimi, K, Masson, A-M M, Squire, J A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385963/
https://www.ncbi.nlm.nih.gov/pubmed/25826225
http://dx.doi.org/10.1038/bjc.2015.81
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