Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study

BACKGROUND: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma. METHODS: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epily...

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Autores principales: Costas, L, Infante-Rivard, C, Zock, J-P, Van Tongeren, M, Boffetta, P, Cusson, A, Robles, C, Casabonne, D, Benavente, Y, Becker, N, Brennan, P, Foretova, L, Maynadié, M, Staines, A, Nieters, A, Cocco, P, de Sanjosé, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385964/
https://www.ncbi.nlm.nih.gov/pubmed/25742473
http://dx.doi.org/10.1038/bjc.2015.83
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author Costas, L
Infante-Rivard, C
Zock, J-P
Van Tongeren, M
Boffetta, P
Cusson, A
Robles, C
Casabonne, D
Benavente, Y
Becker, N
Brennan, P
Foretova, L
Maynadié, M
Staines, A
Nieters, A
Cocco, P
de Sanjosé, S
author_facet Costas, L
Infante-Rivard, C
Zock, J-P
Van Tongeren, M
Boffetta, P
Cusson, A
Robles, C
Casabonne, D
Benavente, Y
Becker, N
Brennan, P
Foretova, L
Maynadié, M
Staines, A
Nieters, A
Cocco, P
de Sanjosé, S
author_sort Costas, L
collection PubMed
description BACKGROUND: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma. METHODS: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study. RESULTS: Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend=0.02). Associations were observed among men, but not women. CONCLUSIONS: Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes.
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spelling pubmed-43859642016-03-31 Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study Costas, L Infante-Rivard, C Zock, J-P Van Tongeren, M Boffetta, P Cusson, A Robles, C Casabonne, D Benavente, Y Becker, N Brennan, P Foretova, L Maynadié, M Staines, A Nieters, A Cocco, P de Sanjosé, S Br J Cancer Epidemiology BACKGROUND: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma. METHODS: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study. RESULTS: Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend=0.02). Associations were observed among men, but not women. CONCLUSIONS: Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes. Nature Publishing Group 2015-03-31 2015-03-05 /pmc/articles/PMC4385964/ /pubmed/25742473 http://dx.doi.org/10.1038/bjc.2015.83 Text en Copyright © 2015 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Epidemiology
Costas, L
Infante-Rivard, C
Zock, J-P
Van Tongeren, M
Boffetta, P
Cusson, A
Robles, C
Casabonne, D
Benavente, Y
Becker, N
Brennan, P
Foretova, L
Maynadié, M
Staines, A
Nieters, A
Cocco, P
de Sanjosé, S
Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study
title Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study
title_full Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study
title_fullStr Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study
title_full_unstemmed Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study
title_short Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study
title_sort occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric european study
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385964/
https://www.ncbi.nlm.nih.gov/pubmed/25742473
http://dx.doi.org/10.1038/bjc.2015.83
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