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Estimating the potential survival gains by eliminating socioeconomic and sex inequalities in stage at diagnosis of melanoma

BACKGROUND: Although inequalities in cancer survival are thought to reflect inequalities in stage at diagnosis, little evidence exists about the size of potential survival gains from eliminating inequalities in stage at diagnosis. METHODS: We used data on patients diagnosed with malignant melanoma i...

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Autores principales: Rutherford, M J, Ironmonger, L, Ormiston-Smith, N, Abel, G A, Greenberg, D C, Lyratzopoulos, G, Lambert, P C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385984/
https://www.ncbi.nlm.nih.gov/pubmed/25734390
http://dx.doi.org/10.1038/bjc.2015.50
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author Rutherford, M J
Ironmonger, L
Ormiston-Smith, N
Abel, G A
Greenberg, D C
Lyratzopoulos, G
Lambert, P C
author_facet Rutherford, M J
Ironmonger, L
Ormiston-Smith, N
Abel, G A
Greenberg, D C
Lyratzopoulos, G
Lambert, P C
author_sort Rutherford, M J
collection PubMed
description BACKGROUND: Although inequalities in cancer survival are thought to reflect inequalities in stage at diagnosis, little evidence exists about the size of potential survival gains from eliminating inequalities in stage at diagnosis. METHODS: We used data on patients diagnosed with malignant melanoma in the East of England (2006–2010) to estimate the number of deaths that could be postponed by completely eliminating socioeconomic and sex differences in stage at diagnosis after fitting a flexible parametric excess mortality model. RESULTS: Stage was a strong predictor of survival. There were pronounced socioeconomic and sex inequalities in the proportion of patients diagnosed at stages III–IV (12 and 8% for least deprived men and women and 25 and 18% for most deprived men and women, respectively). For an annual cohort of 1025 incident cases in the East of England, eliminating sex and deprivation differences in stage at diagnosis would postpone approximately 24 deaths to beyond 5 years from diagnosis. Using appropriate weighting, the equivalent estimate for England would be around 215 deaths, representing 11% of all deaths observed within 5 years from diagnosis in this population. CONCLUSIONS: Reducing socioeconomic and sex inequalities in stage at diagnosis would result in substantial reductions in deaths within 5 years of a melanoma diagnosis.
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spelling pubmed-43859842015-04-07 Estimating the potential survival gains by eliminating socioeconomic and sex inequalities in stage at diagnosis of melanoma Rutherford, M J Ironmonger, L Ormiston-Smith, N Abel, G A Greenberg, D C Lyratzopoulos, G Lambert, P C Br J Cancer Full Paper BACKGROUND: Although inequalities in cancer survival are thought to reflect inequalities in stage at diagnosis, little evidence exists about the size of potential survival gains from eliminating inequalities in stage at diagnosis. METHODS: We used data on patients diagnosed with malignant melanoma in the East of England (2006–2010) to estimate the number of deaths that could be postponed by completely eliminating socioeconomic and sex differences in stage at diagnosis after fitting a flexible parametric excess mortality model. RESULTS: Stage was a strong predictor of survival. There were pronounced socioeconomic and sex inequalities in the proportion of patients diagnosed at stages III–IV (12 and 8% for least deprived men and women and 25 and 18% for most deprived men and women, respectively). For an annual cohort of 1025 incident cases in the East of England, eliminating sex and deprivation differences in stage at diagnosis would postpone approximately 24 deaths to beyond 5 years from diagnosis. Using appropriate weighting, the equivalent estimate for England would be around 215 deaths, representing 11% of all deaths observed within 5 years from diagnosis in this population. CONCLUSIONS: Reducing socioeconomic and sex inequalities in stage at diagnosis would result in substantial reductions in deaths within 5 years of a melanoma diagnosis. Nature Publishing Group 2015-03-31 2015-03-03 /pmc/articles/PMC4385984/ /pubmed/25734390 http://dx.doi.org/10.1038/bjc.2015.50 Text en Copyright © 2015 Cancer Research UK http://creativecommons.org/licenses/by/4.0/ This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Full Paper
Rutherford, M J
Ironmonger, L
Ormiston-Smith, N
Abel, G A
Greenberg, D C
Lyratzopoulos, G
Lambert, P C
Estimating the potential survival gains by eliminating socioeconomic and sex inequalities in stage at diagnosis of melanoma
title Estimating the potential survival gains by eliminating socioeconomic and sex inequalities in stage at diagnosis of melanoma
title_full Estimating the potential survival gains by eliminating socioeconomic and sex inequalities in stage at diagnosis of melanoma
title_fullStr Estimating the potential survival gains by eliminating socioeconomic and sex inequalities in stage at diagnosis of melanoma
title_full_unstemmed Estimating the potential survival gains by eliminating socioeconomic and sex inequalities in stage at diagnosis of melanoma
title_short Estimating the potential survival gains by eliminating socioeconomic and sex inequalities in stage at diagnosis of melanoma
title_sort estimating the potential survival gains by eliminating socioeconomic and sex inequalities in stage at diagnosis of melanoma
topic Full Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385984/
https://www.ncbi.nlm.nih.gov/pubmed/25734390
http://dx.doi.org/10.1038/bjc.2015.50
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