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Infant Arterial Stiffness and Maternal Iron Status in Pregnancy: A UK Birth Cohort (Baby VIP Study)

BACKGROUND: In animal studies, iron deficiency during pregnancy has been linked to increased offspring cardiovascular risk. No previous population studies have measured arterial stiffness early in life to examine its association with maternal iron status. OBJECTIVE: This study aimed to examine the a...

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Autores principales: Alwan, Nisreen A., Cade, Janet E., McArdle, Harry J., Greenwood, Darren C., Hayes, Helen E., Ciantar, Etienne, Simpson, Nigel A.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386106/
https://www.ncbi.nlm.nih.gov/pubmed/25790854
http://dx.doi.org/10.1159/000377618
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author Alwan, Nisreen A.
Cade, Janet E.
McArdle, Harry J.
Greenwood, Darren C.
Hayes, Helen E.
Ciantar, Etienne
Simpson, Nigel A.B.
author_facet Alwan, Nisreen A.
Cade, Janet E.
McArdle, Harry J.
Greenwood, Darren C.
Hayes, Helen E.
Ciantar, Etienne
Simpson, Nigel A.B.
author_sort Alwan, Nisreen A.
collection PubMed
description BACKGROUND: In animal studies, iron deficiency during pregnancy has been linked to increased offspring cardiovascular risk. No previous population studies have measured arterial stiffness early in life to examine its association with maternal iron status. OBJECTIVE: This study aimed to examine the association between maternal iron status in early pregnancy with infant brachio-femoral pulse wave velocity (PWV). METHODS: The Baby VIP (Baby's Vascular Health and Iron in Pregnancy) study is a UK-based birth cohort which recruited 362 women after delivery from the Leeds Teaching Hospitals postnatal wards. Ferritin and transferrin receptor levels were measured in maternal serum samples previously obtained in the first trimester. Infant brachio-femoral PWV was measured during a home visit at 2–6 weeks. RESULTS: Iron depletion (ferritin <15 µg/l) was detected in 79 (23%) women in early pregnancy. Infant PWV (mean = 6.7 m/s, SD = 1.3, n = 284) was neither associated with maternal ferritin (adjusted change per 10 µg/l = 0.02, 95% CI: −0.01, 0.1), nor with iron depletion (adjusted change = −0.2, 95% CI: −0.6, 0.2). No evidence of association was observed between maternal serum transferrin receptor level and its ratio to ferritin with infant PWV. Maternal anaemia (<11 g/dl) at <20 weeks’ gestation was associated with a 1.0-m/s increase in infant PWV (adjusted 95% CI: 0.1, 1.9). CONCLUSION: This is the largest study to date which has assessed peripheral PWV as a measure of arterial stiffness in infants. There was no evidence of an association between markers of maternal iron status early in pregnancy and infant PWV.
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spelling pubmed-43861062015-05-08 Infant Arterial Stiffness and Maternal Iron Status in Pregnancy: A UK Birth Cohort (Baby VIP Study) Alwan, Nisreen A. Cade, Janet E. McArdle, Harry J. Greenwood, Darren C. Hayes, Helen E. Ciantar, Etienne Simpson, Nigel A.B. Neonatology Published online: March, 2015 BACKGROUND: In animal studies, iron deficiency during pregnancy has been linked to increased offspring cardiovascular risk. No previous population studies have measured arterial stiffness early in life to examine its association with maternal iron status. OBJECTIVE: This study aimed to examine the association between maternal iron status in early pregnancy with infant brachio-femoral pulse wave velocity (PWV). METHODS: The Baby VIP (Baby's Vascular Health and Iron in Pregnancy) study is a UK-based birth cohort which recruited 362 women after delivery from the Leeds Teaching Hospitals postnatal wards. Ferritin and transferrin receptor levels were measured in maternal serum samples previously obtained in the first trimester. Infant brachio-femoral PWV was measured during a home visit at 2–6 weeks. RESULTS: Iron depletion (ferritin <15 µg/l) was detected in 79 (23%) women in early pregnancy. Infant PWV (mean = 6.7 m/s, SD = 1.3, n = 284) was neither associated with maternal ferritin (adjusted change per 10 µg/l = 0.02, 95% CI: −0.01, 0.1), nor with iron depletion (adjusted change = −0.2, 95% CI: −0.6, 0.2). No evidence of association was observed between maternal serum transferrin receptor level and its ratio to ferritin with infant PWV. Maternal anaemia (<11 g/dl) at <20 weeks’ gestation was associated with a 1.0-m/s increase in infant PWV (adjusted 95% CI: 0.1, 1.9). CONCLUSION: This is the largest study to date which has assessed peripheral PWV as a measure of arterial stiffness in infants. There was no evidence of an association between markers of maternal iron status early in pregnancy and infant PWV. S. Karger AG 2015-01 2015-03-12 /pmc/articles/PMC4386106/ /pubmed/25790854 http://dx.doi.org/10.1159/000377618 Text en Copyright © 2015 by S. Karger AG, Basel http://creativecommons.org/licenses/by/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution 3.0 Unported license (CC BY 3.0) (www.karger.com/OA-license-WT), applicable to the online version of the article only. Users may download, print and share this work on the Internet, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: March, 2015
Alwan, Nisreen A.
Cade, Janet E.
McArdle, Harry J.
Greenwood, Darren C.
Hayes, Helen E.
Ciantar, Etienne
Simpson, Nigel A.B.
Infant Arterial Stiffness and Maternal Iron Status in Pregnancy: A UK Birth Cohort (Baby VIP Study)
title Infant Arterial Stiffness and Maternal Iron Status in Pregnancy: A UK Birth Cohort (Baby VIP Study)
title_full Infant Arterial Stiffness and Maternal Iron Status in Pregnancy: A UK Birth Cohort (Baby VIP Study)
title_fullStr Infant Arterial Stiffness and Maternal Iron Status in Pregnancy: A UK Birth Cohort (Baby VIP Study)
title_full_unstemmed Infant Arterial Stiffness and Maternal Iron Status in Pregnancy: A UK Birth Cohort (Baby VIP Study)
title_short Infant Arterial Stiffness and Maternal Iron Status in Pregnancy: A UK Birth Cohort (Baby VIP Study)
title_sort infant arterial stiffness and maternal iron status in pregnancy: a uk birth cohort (baby vip study)
topic Published online: March, 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386106/
https://www.ncbi.nlm.nih.gov/pubmed/25790854
http://dx.doi.org/10.1159/000377618
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