Reduced Sympathetic Response to Head-Up Tilt in Subjects with Mild Cognitive Impairment or Mild Alzheimer's Dementia

BACKGROUND: Hemodynamic control was compared in patients with mild cognitive impairment (MCI) or mild Alzheimer's dementia (AD) as well as in healthy elderly subjects. METHODS: Noninvasive, continuous hemodynamic recordings were obtained from 14 patients and 48 controls during supine rest (tilt...

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Autores principales: Mellingsæter, Marte Rognstad, Wyller, Torgeir Bruun, Ranhoff, Anette Hylen, Bogdanovic, Nenad, Wyller, Vegard Bruun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2015
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386107/
https://www.ncbi.nlm.nih.gov/pubmed/25873932
http://dx.doi.org/10.1159/000375297
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author Mellingsæter, Marte Rognstad
Wyller, Torgeir Bruun
Ranhoff, Anette Hylen
Bogdanovic, Nenad
Wyller, Vegard Bruun
author_facet Mellingsæter, Marte Rognstad
Wyller, Torgeir Bruun
Ranhoff, Anette Hylen
Bogdanovic, Nenad
Wyller, Vegard Bruun
author_sort Mellingsæter, Marte Rognstad
collection PubMed
description BACKGROUND: Hemodynamic control was compared in patients with mild cognitive impairment (MCI) or mild Alzheimer's dementia (AD) as well as in healthy elderly subjects. METHODS: Noninvasive, continuous hemodynamic recordings were obtained from 14 patients and 48 controls during supine rest (tilt of 30 and 70°). Cardiac output, end-diastolic volume, total peripheral resistance, heart rate variability (HRV), systolic blood pressure variability (SBPV), and baroreceptor sensitivity were calculated. RESULTS: At 70° tilt, the HRV indices differed significantly, with higher high-frequency (HF) variability as well as lower low-frequency (LF) variability and LF/HF ratios in the patients. The patients had significantly lower SBPV in the LF range at 30° tilt. CONCLUSIONS: The results indicate a poorer sympathetic response to orthostatic stress in MCI and mild AD. © 2015 S. Karger AG, Basel
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spelling pubmed-43861072015-04-14 Reduced Sympathetic Response to Head-Up Tilt in Subjects with Mild Cognitive Impairment or Mild Alzheimer's Dementia Mellingsæter, Marte Rognstad Wyller, Torgeir Bruun Ranhoff, Anette Hylen Bogdanovic, Nenad Wyller, Vegard Bruun Dement Geriatr Cogn Dis Extra Original Research Article BACKGROUND: Hemodynamic control was compared in patients with mild cognitive impairment (MCI) or mild Alzheimer's dementia (AD) as well as in healthy elderly subjects. METHODS: Noninvasive, continuous hemodynamic recordings were obtained from 14 patients and 48 controls during supine rest (tilt of 30 and 70°). Cardiac output, end-diastolic volume, total peripheral resistance, heart rate variability (HRV), systolic blood pressure variability (SBPV), and baroreceptor sensitivity were calculated. RESULTS: At 70° tilt, the HRV indices differed significantly, with higher high-frequency (HF) variability as well as lower low-frequency (LF) variability and LF/HF ratios in the patients. The patients had significantly lower SBPV in the LF range at 30° tilt. CONCLUSIONS: The results indicate a poorer sympathetic response to orthostatic stress in MCI and mild AD. © 2015 S. Karger AG, Basel S. Karger AG 2015-03-13 /pmc/articles/PMC4386107/ /pubmed/25873932 http://dx.doi.org/10.1159/000375297 Text en Copyright © 2015 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Original Research Article
Mellingsæter, Marte Rognstad
Wyller, Torgeir Bruun
Ranhoff, Anette Hylen
Bogdanovic, Nenad
Wyller, Vegard Bruun
Reduced Sympathetic Response to Head-Up Tilt in Subjects with Mild Cognitive Impairment or Mild Alzheimer's Dementia
title Reduced Sympathetic Response to Head-Up Tilt in Subjects with Mild Cognitive Impairment or Mild Alzheimer's Dementia
title_full Reduced Sympathetic Response to Head-Up Tilt in Subjects with Mild Cognitive Impairment or Mild Alzheimer's Dementia
title_fullStr Reduced Sympathetic Response to Head-Up Tilt in Subjects with Mild Cognitive Impairment or Mild Alzheimer's Dementia
title_full_unstemmed Reduced Sympathetic Response to Head-Up Tilt in Subjects with Mild Cognitive Impairment or Mild Alzheimer's Dementia
title_short Reduced Sympathetic Response to Head-Up Tilt in Subjects with Mild Cognitive Impairment or Mild Alzheimer's Dementia
title_sort reduced sympathetic response to head-up tilt in subjects with mild cognitive impairment or mild alzheimer's dementia
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386107/
https://www.ncbi.nlm.nih.gov/pubmed/25873932
http://dx.doi.org/10.1159/000375297
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