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Effect of a combination of duloxetine with hydroxyzine on experimental models of anxiety in mice

OBJECTIVE: There is a strong association between depression and anxiety. Duloxetine, an antidepressant agent, is also used in the treatment of anxiety. Hydroxyzine is preferred over benzodiazepines in the treatment of anxiety. Present study was designed to study the impact of a combination of duloxe...

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Autores principales: Patel, Sonam, Kale, Pravin Popatrao, Addepalli, Veeranjaneyulu, Sarkar, Amrita, Savai, Jay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386125/
https://www.ncbi.nlm.nih.gov/pubmed/25878376
http://dx.doi.org/10.4103/0253-7613.153424
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author Patel, Sonam
Kale, Pravin Popatrao
Addepalli, Veeranjaneyulu
Sarkar, Amrita
Savai, Jay
author_facet Patel, Sonam
Kale, Pravin Popatrao
Addepalli, Veeranjaneyulu
Sarkar, Amrita
Savai, Jay
author_sort Patel, Sonam
collection PubMed
description OBJECTIVE: There is a strong association between depression and anxiety. Duloxetine, an antidepressant agent, is also used in the treatment of anxiety. Hydroxyzine is preferred over benzodiazepines in the treatment of anxiety. Present study was designed to study the impact of a combination of duloxetine with hydroxyzine in treatment of anxiety. MATERIALS AND METHODS: Mice received intraperitoneal injection of normal saline (10 ml/kg), duloxetine alone (10 mg/kg), hydroxyzine alone (10 mg/kg), and hydroxyzine plus duloxetine (5 mg/kg, each). RESULTS: The in vivo results (elevated plus maze and light/dark transition tests) showed significant anxiolytic activity with the hydroxyzine treatment than the control group. The brain monoamines were significantly increased in hippocampi, cerebral cortices, and whole brain in drug-treated groups than in the control group. The group receiving the combination showed similar results in the in vivo models and in vitro tests (brain monoamine estimations) than respective monotherapies, with the exception of a greater increase of norepinephrine levels in cerebral cortices in duloxetine-treated group. CONCLUSION: Combination of duloxetine with hydroxyzine is not beneficial in anxiolytic treatment than the respective monotherapies. There is a need to study the pharmacokinetic drug-drug interactions to understand the present study outcomes.
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spelling pubmed-43861252015-04-15 Effect of a combination of duloxetine with hydroxyzine on experimental models of anxiety in mice Patel, Sonam Kale, Pravin Popatrao Addepalli, Veeranjaneyulu Sarkar, Amrita Savai, Jay Indian J Pharmacol Research Article OBJECTIVE: There is a strong association between depression and anxiety. Duloxetine, an antidepressant agent, is also used in the treatment of anxiety. Hydroxyzine is preferred over benzodiazepines in the treatment of anxiety. Present study was designed to study the impact of a combination of duloxetine with hydroxyzine in treatment of anxiety. MATERIALS AND METHODS: Mice received intraperitoneal injection of normal saline (10 ml/kg), duloxetine alone (10 mg/kg), hydroxyzine alone (10 mg/kg), and hydroxyzine plus duloxetine (5 mg/kg, each). RESULTS: The in vivo results (elevated plus maze and light/dark transition tests) showed significant anxiolytic activity with the hydroxyzine treatment than the control group. The brain monoamines were significantly increased in hippocampi, cerebral cortices, and whole brain in drug-treated groups than in the control group. The group receiving the combination showed similar results in the in vivo models and in vitro tests (brain monoamine estimations) than respective monotherapies, with the exception of a greater increase of norepinephrine levels in cerebral cortices in duloxetine-treated group. CONCLUSION: Combination of duloxetine with hydroxyzine is not beneficial in anxiolytic treatment than the respective monotherapies. There is a need to study the pharmacokinetic drug-drug interactions to understand the present study outcomes. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4386125/ /pubmed/25878376 http://dx.doi.org/10.4103/0253-7613.153424 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Patel, Sonam
Kale, Pravin Popatrao
Addepalli, Veeranjaneyulu
Sarkar, Amrita
Savai, Jay
Effect of a combination of duloxetine with hydroxyzine on experimental models of anxiety in mice
title Effect of a combination of duloxetine with hydroxyzine on experimental models of anxiety in mice
title_full Effect of a combination of duloxetine with hydroxyzine on experimental models of anxiety in mice
title_fullStr Effect of a combination of duloxetine with hydroxyzine on experimental models of anxiety in mice
title_full_unstemmed Effect of a combination of duloxetine with hydroxyzine on experimental models of anxiety in mice
title_short Effect of a combination of duloxetine with hydroxyzine on experimental models of anxiety in mice
title_sort effect of a combination of duloxetine with hydroxyzine on experimental models of anxiety in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386125/
https://www.ncbi.nlm.nih.gov/pubmed/25878376
http://dx.doi.org/10.4103/0253-7613.153424
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