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Florbetaben for PET Imaging of Beta-Amyloid Plaques in the Brain
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder affecting the elderly. Current clinical diagnostic tools are often ineffective in accurately diagnosing AD. However, new advances in diagnostic imaging, particularly positron emission tomography (PET) amyloid imaging, have shown in...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Healthcare
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386430/ https://www.ncbi.nlm.nih.gov/pubmed/26000224 http://dx.doi.org/10.1007/s40120-014-0022-9 |
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author | Richards, Danielle Sabbagh, Marwan N. |
author_facet | Richards, Danielle Sabbagh, Marwan N. |
author_sort | Richards, Danielle |
collection | PubMed |
description | Alzheimer’s disease (AD) is a devastating neurodegenerative disorder affecting the elderly. Current clinical diagnostic tools are often ineffective in accurately diagnosing AD. However, new advances in diagnostic imaging, particularly positron emission tomography (PET) amyloid imaging, have shown increased sensitivity and specificity, as well as high inter-reader agreement. The most commonly studied tracer, PiB-C11, has shown high affinity binding to amyloid, but is limited in its use outside of research due to its short half-life. Instead, development of other PET ligands with increased half-life, such as fluorine-18-labeled ((18)F) tracers, allows for more widespread use of PET in clinical settings. In particular, recent phase II and III trials of (18)F-florbetaben have demonstrated the high accuracy of this PET tracer in identifying amyloid accumulation. This paper will examine the techniques of amyloid imaging, focusing particularly on the recently approved (18)F-florbetaben. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40120-014-0022-9) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4386430 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-43864302015-05-21 Florbetaben for PET Imaging of Beta-Amyloid Plaques in the Brain Richards, Danielle Sabbagh, Marwan N. Neurol Ther Review Alzheimer’s disease (AD) is a devastating neurodegenerative disorder affecting the elderly. Current clinical diagnostic tools are often ineffective in accurately diagnosing AD. However, new advances in diagnostic imaging, particularly positron emission tomography (PET) amyloid imaging, have shown increased sensitivity and specificity, as well as high inter-reader agreement. The most commonly studied tracer, PiB-C11, has shown high affinity binding to amyloid, but is limited in its use outside of research due to its short half-life. Instead, development of other PET ligands with increased half-life, such as fluorine-18-labeled ((18)F) tracers, allows for more widespread use of PET in clinical settings. In particular, recent phase II and III trials of (18)F-florbetaben have demonstrated the high accuracy of this PET tracer in identifying amyloid accumulation. This paper will examine the techniques of amyloid imaging, focusing particularly on the recently approved (18)F-florbetaben. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s40120-014-0022-9) contains supplementary material, which is available to authorized users. Springer Healthcare 2014-11-27 /pmc/articles/PMC4386430/ /pubmed/26000224 http://dx.doi.org/10.1007/s40120-014-0022-9 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Review Richards, Danielle Sabbagh, Marwan N. Florbetaben for PET Imaging of Beta-Amyloid Plaques in the Brain |
title | Florbetaben for PET Imaging of Beta-Amyloid Plaques in the Brain |
title_full | Florbetaben for PET Imaging of Beta-Amyloid Plaques in the Brain |
title_fullStr | Florbetaben for PET Imaging of Beta-Amyloid Plaques in the Brain |
title_full_unstemmed | Florbetaben for PET Imaging of Beta-Amyloid Plaques in the Brain |
title_short | Florbetaben for PET Imaging of Beta-Amyloid Plaques in the Brain |
title_sort | florbetaben for pet imaging of beta-amyloid plaques in the brain |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386430/ https://www.ncbi.nlm.nih.gov/pubmed/26000224 http://dx.doi.org/10.1007/s40120-014-0022-9 |
work_keys_str_mv | AT richardsdanielle florbetabenforpetimagingofbetaamyloidplaquesinthebrain AT sabbaghmarwann florbetabenforpetimagingofbetaamyloidplaquesinthebrain |