Restoring Susceptibility Induced MRI Signal Loss in Rat Brain at 9.4 T: A Step towards Whole Brain Functional Connectivity Imaging

The aural cavity magnetic susceptibility artifact leads to significant echo planar imaging (EPI) signal dropout in rat deep brain that limits acquisition of functional connectivity fcMRI data. In this study, we provide a method that recovers much of the EPI signal in deep brain. Needle puncture intr...

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Detalles Bibliográficos
Autores principales: Li, Rupeng, Liu, Xiping, Sidabras, Jason W., Paulson, Eric S., Jesmanowicz, Andrzej, Nencka, Andrew S., Hudetz, Anthony G., Hyde, James S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386820/
https://www.ncbi.nlm.nih.gov/pubmed/25844644
http://dx.doi.org/10.1371/journal.pone.0119450
Descripción
Sumario:The aural cavity magnetic susceptibility artifact leads to significant echo planar imaging (EPI) signal dropout in rat deep brain that limits acquisition of functional connectivity fcMRI data. In this study, we provide a method that recovers much of the EPI signal in deep brain. Needle puncture introduction of a liquid-phase fluorocarbon into the middle ear allows acquisition of rat fcMRI data without signal dropout. We demonstrate that with seeds chosen from previously unavailable areas, including the amygdala and the insular cortex, we are able to acquire large scale networks, including the limbic system. This tool allows EPI-based neuroscience and pharmaceutical research in rat brain using fcMRI that was previously not feasible.

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