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Electrical Properties of Isolated Cardiomyocytes in a Rat Model of Thiamine Deficiency
In modern society, thiamine deficiency (TD) remains an important medical condition linked to altered cardiac function. There have been contradictory reports about the impact of TD on heart physiology, especially in the context of cardiac excitability. In order to address this particular question, we...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Cardiologia
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386853/ https://www.ncbi.nlm.nih.gov/pubmed/25884771 http://dx.doi.org/10.5935/abc.20150010 |
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author | Santos-Miranda, Artur Cruz, Jader Santos Roman-Campos, Danilo |
author_facet | Santos-Miranda, Artur Cruz, Jader Santos Roman-Campos, Danilo |
author_sort | Santos-Miranda, Artur |
collection | PubMed |
description | In modern society, thiamine deficiency (TD) remains an important medical condition linked to altered cardiac function. There have been contradictory reports about the impact of TD on heart physiology, especially in the context of cardiac excitability. In order to address this particular question, we used a TD rat model and patch-clamp technique to investigate the electrical properties of isolated cardiomyocytes from epicardium and endocardium. Neither cell type showed substantial differences on the action potential waveform and transient outward potassium current. Based on our results we can conclude that TD does not induce major electrical remodeling in isolated cardiac myocytes in either endocardium or epicardium cells. |
format | Online Article Text |
id | pubmed-4386853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Sociedade Brasileira de Cardiologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-43868532015-04-07 Electrical Properties of Isolated Cardiomyocytes in a Rat Model of Thiamine Deficiency Santos-Miranda, Artur Cruz, Jader Santos Roman-Campos, Danilo Arq Bras Cardiol Brief Communication In modern society, thiamine deficiency (TD) remains an important medical condition linked to altered cardiac function. There have been contradictory reports about the impact of TD on heart physiology, especially in the context of cardiac excitability. In order to address this particular question, we used a TD rat model and patch-clamp technique to investigate the electrical properties of isolated cardiomyocytes from epicardium and endocardium. Neither cell type showed substantial differences on the action potential waveform and transient outward potassium current. Based on our results we can conclude that TD does not induce major electrical remodeling in isolated cardiac myocytes in either endocardium or epicardium cells. Sociedade Brasileira de Cardiologia 2015-03 /pmc/articles/PMC4386853/ /pubmed/25884771 http://dx.doi.org/10.5935/abc.20150010 Text en http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution NonCommercial License which permits unrestricted noncommercial use, distribution, and reproduction in any medium provided the original work is properly cited. |
spellingShingle | Brief Communication Santos-Miranda, Artur Cruz, Jader Santos Roman-Campos, Danilo Electrical Properties of Isolated Cardiomyocytes in a Rat Model of Thiamine Deficiency |
title | Electrical Properties of Isolated Cardiomyocytes in a Rat Model of
Thiamine Deficiency |
title_full | Electrical Properties of Isolated Cardiomyocytes in a Rat Model of
Thiamine Deficiency |
title_fullStr | Electrical Properties of Isolated Cardiomyocytes in a Rat Model of
Thiamine Deficiency |
title_full_unstemmed | Electrical Properties of Isolated Cardiomyocytes in a Rat Model of
Thiamine Deficiency |
title_short | Electrical Properties of Isolated Cardiomyocytes in a Rat Model of
Thiamine Deficiency |
title_sort | electrical properties of isolated cardiomyocytes in a rat model of
thiamine deficiency |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386853/ https://www.ncbi.nlm.nih.gov/pubmed/25884771 http://dx.doi.org/10.5935/abc.20150010 |
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