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T cell lipid peroxidation induces ferroptosis and prevents immunity to infection

The selenoenzyme glutathione peroxidase 4 (Gpx4) is a major scavenger of phospholipid hydroperoxides. Although Gpx4 represents a key component of the reactive oxygen species-scavenging network, its relevance in the immune system is yet to be defined. Here, we investigated the importance of Gpx4 for...

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Detalles Bibliográficos
Autores principales: Matsushita, Mai, Freigang, Stefan, Schneider, Christoph, Conrad, Marcus, Bornkamm, Georg W., Kopf, Manfred
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387287/
https://www.ncbi.nlm.nih.gov/pubmed/25824823
http://dx.doi.org/10.1084/jem.20140857

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