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T cell lipid peroxidation induces ferroptosis and prevents immunity to infection
The selenoenzyme glutathione peroxidase 4 (Gpx4) is a major scavenger of phospholipid hydroperoxides. Although Gpx4 represents a key component of the reactive oxygen species-scavenging network, its relevance in the immune system is yet to be defined. Here, we investigated the importance of Gpx4 for...
Autores principales: | Matsushita, Mai, Freigang, Stefan, Schneider, Christoph, Conrad, Marcus, Bornkamm, Georg W., Kopf, Manfred |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387287/ https://www.ncbi.nlm.nih.gov/pubmed/25824823 http://dx.doi.org/10.1084/jem.20140857 |
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