SMARCE1 suppresses EGFR expression and controls responses to MET and ALK inhibitors in lung cancer

Recurrent inactivating mutations in components of SWI/SNF chromatin-remodeling complexes have been identified across cancer types, supporting their roles as tumor suppressors in modulating oncogenic signaling pathways. We report here that SMARCE1 loss induces EGFR expression and confers resistance t...

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Detalles Bibliográficos
Autores principales: Papadakis, Andreas I, Sun, Chong, Knijnenburg, Theo A, Xue, Yibo, Grernrum, Wipawadee, Hölzel, Michael, Nijkamp, Wouter, Wessels, Lodewyk FA, Beijersbergen, Roderick L, Bernards, Rene, Huang, Sidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387553/
https://www.ncbi.nlm.nih.gov/pubmed/25656847
http://dx.doi.org/10.1038/cr.2015.16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387553/
https://www.ncbi.nlm.nih.gov/pubmed/25656847
http://dx.doi.org/10.1038/cr.2015.16

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