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Effects of PDE type 5 inhibitors on Left Ventricular Diastolic Dysfunction in Resistant Hypertension
Resistant hypertension (RHTN) is a multifactorial disease characterized by blood pressure (BP) levels above goal (140/90 mmHg) in spite of the concurrent use of three or more antihypertensive drugs of different classes. Moreover, it is well known that RHTN subjects have high prevalence of left ventr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Cardiologia
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387615/ https://www.ncbi.nlm.nih.gov/pubmed/25352458 http://dx.doi.org/10.5935/abc.20140159 |
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author | de Faria, Ana Paula Cabral Modolo, Rodrigo Moreno, Beatriz Vaz Domingues Moreno, Heitor |
author_facet | de Faria, Ana Paula Cabral Modolo, Rodrigo Moreno, Beatriz Vaz Domingues Moreno, Heitor |
author_sort | de Faria, Ana Paula Cabral |
collection | PubMed |
description | Resistant hypertension (RHTN) is a multifactorial disease characterized by blood pressure (BP) levels above goal (140/90 mmHg) in spite of the concurrent use of three or more antihypertensive drugs of different classes. Moreover, it is well known that RHTN subjects have high prevalence of left ventricular diastolic dysfunction (LVDD), which leads to increased risk of heart failure progression. This review gathers data from studies evaluating the effects of phosphodiesterase-5 (PDE-5) inhibitors (administration of acute sildenafil and short-term tadalafil) on diastolic function, biochemical and hemodynamic parameters in patients with RHTN. Acute study with sildenafil treatment found that inhibition of PDE-5 improved hemodynamic parameters and diastolic relaxation. In addition, short-term study with the use of tadalafil demonstrated improvement of LVDD, cGMP and BNP-32 levels, regardless of BP reduction. No endothelial function changes were observed in the studies. The findings of acute and short-term studies revealed potential therapeutic effects of IPDE-5 drugs on LVDD in RHTN patients. |
format | Online Article Text |
id | pubmed-4387615 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Sociedade Brasileira de Cardiologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-43876152015-04-08 Effects of PDE type 5 inhibitors on Left Ventricular Diastolic Dysfunction in Resistant Hypertension de Faria, Ana Paula Cabral Modolo, Rodrigo Moreno, Beatriz Vaz Domingues Moreno, Heitor Arq Bras Cardiol Review Article Resistant hypertension (RHTN) is a multifactorial disease characterized by blood pressure (BP) levels above goal (140/90 mmHg) in spite of the concurrent use of three or more antihypertensive drugs of different classes. Moreover, it is well known that RHTN subjects have high prevalence of left ventricular diastolic dysfunction (LVDD), which leads to increased risk of heart failure progression. This review gathers data from studies evaluating the effects of phosphodiesterase-5 (PDE-5) inhibitors (administration of acute sildenafil and short-term tadalafil) on diastolic function, biochemical and hemodynamic parameters in patients with RHTN. Acute study with sildenafil treatment found that inhibition of PDE-5 improved hemodynamic parameters and diastolic relaxation. In addition, short-term study with the use of tadalafil demonstrated improvement of LVDD, cGMP and BNP-32 levels, regardless of BP reduction. No endothelial function changes were observed in the studies. The findings of acute and short-term studies revealed potential therapeutic effects of IPDE-5 drugs on LVDD in RHTN patients. Sociedade Brasileira de Cardiologia 2015-01 /pmc/articles/PMC4387615/ /pubmed/25352458 http://dx.doi.org/10.5935/abc.20140159 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article de Faria, Ana Paula Cabral Modolo, Rodrigo Moreno, Beatriz Vaz Domingues Moreno, Heitor Effects of PDE type 5 inhibitors on Left Ventricular Diastolic Dysfunction in Resistant Hypertension |
title | Effects of PDE type 5 inhibitors on Left Ventricular Diastolic
Dysfunction in Resistant Hypertension |
title_full | Effects of PDE type 5 inhibitors on Left Ventricular Diastolic
Dysfunction in Resistant Hypertension |
title_fullStr | Effects of PDE type 5 inhibitors on Left Ventricular Diastolic
Dysfunction in Resistant Hypertension |
title_full_unstemmed | Effects of PDE type 5 inhibitors on Left Ventricular Diastolic
Dysfunction in Resistant Hypertension |
title_short | Effects of PDE type 5 inhibitors on Left Ventricular Diastolic
Dysfunction in Resistant Hypertension |
title_sort | effects of pde type 5 inhibitors on left ventricular diastolic
dysfunction in resistant hypertension |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387615/ https://www.ncbi.nlm.nih.gov/pubmed/25352458 http://dx.doi.org/10.5935/abc.20140159 |
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