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Effects of PDE type 5 inhibitors on Left Ventricular Diastolic Dysfunction in Resistant Hypertension

Resistant hypertension (RHTN) is a multifactorial disease characterized by blood pressure (BP) levels above goal (140/90 mmHg) in spite of the concurrent use of three or more antihypertensive drugs of different classes. Moreover, it is well known that RHTN subjects have high prevalence of left ventr...

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Autores principales: de Faria, Ana Paula Cabral, Modolo, Rodrigo, Moreno, Beatriz Vaz Domingues, Moreno, Heitor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Cardiologia 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387615/
https://www.ncbi.nlm.nih.gov/pubmed/25352458
http://dx.doi.org/10.5935/abc.20140159
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author de Faria, Ana Paula Cabral
Modolo, Rodrigo
Moreno, Beatriz Vaz Domingues
Moreno, Heitor
author_facet de Faria, Ana Paula Cabral
Modolo, Rodrigo
Moreno, Beatriz Vaz Domingues
Moreno, Heitor
author_sort de Faria, Ana Paula Cabral
collection PubMed
description Resistant hypertension (RHTN) is a multifactorial disease characterized by blood pressure (BP) levels above goal (140/90 mmHg) in spite of the concurrent use of three or more antihypertensive drugs of different classes. Moreover, it is well known that RHTN subjects have high prevalence of left ventricular diastolic dysfunction (LVDD), which leads to increased risk of heart failure progression. This review gathers data from studies evaluating the effects of phosphodiesterase-5 (PDE-5) inhibitors (administration of acute sildenafil and short-term tadalafil) on diastolic function, biochemical and hemodynamic parameters in patients with RHTN. Acute study with sildenafil treatment found that inhibition of PDE-5 improved hemodynamic parameters and diastolic relaxation. In addition, short-term study with the use of tadalafil demonstrated improvement of LVDD, cGMP and BNP-32 levels, regardless of BP reduction. No endothelial function changes were observed in the studies. The findings of acute and short-term studies revealed potential therapeutic effects of IPDE-5 drugs on LVDD in RHTN patients.
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spelling pubmed-43876152015-04-08 Effects of PDE type 5 inhibitors on Left Ventricular Diastolic Dysfunction in Resistant Hypertension de Faria, Ana Paula Cabral Modolo, Rodrigo Moreno, Beatriz Vaz Domingues Moreno, Heitor Arq Bras Cardiol Review Article Resistant hypertension (RHTN) is a multifactorial disease characterized by blood pressure (BP) levels above goal (140/90 mmHg) in spite of the concurrent use of three or more antihypertensive drugs of different classes. Moreover, it is well known that RHTN subjects have high prevalence of left ventricular diastolic dysfunction (LVDD), which leads to increased risk of heart failure progression. This review gathers data from studies evaluating the effects of phosphodiesterase-5 (PDE-5) inhibitors (administration of acute sildenafil and short-term tadalafil) on diastolic function, biochemical and hemodynamic parameters in patients with RHTN. Acute study with sildenafil treatment found that inhibition of PDE-5 improved hemodynamic parameters and diastolic relaxation. In addition, short-term study with the use of tadalafil demonstrated improvement of LVDD, cGMP and BNP-32 levels, regardless of BP reduction. No endothelial function changes were observed in the studies. The findings of acute and short-term studies revealed potential therapeutic effects of IPDE-5 drugs on LVDD in RHTN patients. Sociedade Brasileira de Cardiologia 2015-01 /pmc/articles/PMC4387615/ /pubmed/25352458 http://dx.doi.org/10.5935/abc.20140159 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
de Faria, Ana Paula Cabral
Modolo, Rodrigo
Moreno, Beatriz Vaz Domingues
Moreno, Heitor
Effects of PDE type 5 inhibitors on Left Ventricular Diastolic Dysfunction in Resistant Hypertension
title Effects of PDE type 5 inhibitors on Left Ventricular Diastolic Dysfunction in Resistant Hypertension
title_full Effects of PDE type 5 inhibitors on Left Ventricular Diastolic Dysfunction in Resistant Hypertension
title_fullStr Effects of PDE type 5 inhibitors on Left Ventricular Diastolic Dysfunction in Resistant Hypertension
title_full_unstemmed Effects of PDE type 5 inhibitors on Left Ventricular Diastolic Dysfunction in Resistant Hypertension
title_short Effects of PDE type 5 inhibitors on Left Ventricular Diastolic Dysfunction in Resistant Hypertension
title_sort effects of pde type 5 inhibitors on left ventricular diastolic dysfunction in resistant hypertension
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387615/
https://www.ncbi.nlm.nih.gov/pubmed/25352458
http://dx.doi.org/10.5935/abc.20140159
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