Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice

In Saccharomyces cerevisiae, absence of the checkpoint kinase Mec1 (ATR) is viable upon mutations that increase the activity of the ribonucleotide reductase (RNR) complex. Whether this pathway is conserved in mammals remains unknown. Here we show that cells from mice carrying extra alleles of the RN...

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Detalles Bibliográficos
Autores principales: Lopez-Contreras, Andres J., Specks, Julia, Barlow, Jacqueline H., Ambrogio, Chiara, Desler, Claus, Vikingsson, Svante, Rodrigo-Perez, Sara, Green, Henrik, Rasmussen, Lene Juel, Murga, Matilde, Nussenzweig, André, Fernandez-Capetillo, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387711/
https://www.ncbi.nlm.nih.gov/pubmed/25838540
http://dx.doi.org/10.1101/gad.256958.114

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