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GRACOMICS: software for graphical comparison of multiple results with omics data
BACKGROUND: Analysis of large-scale omics data has become more and more challenging due to high dimensionality. More complex analysis methods and tools are required to handle such data. While many methods already exist, those methods often produce different results. To help users obtain more appropr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387734/ https://www.ncbi.nlm.nih.gov/pubmed/25887412 http://dx.doi.org/10.1186/s12864-015-1461-0 |
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author | Seo, Minseok Yoon, Joon Park, Taesung |
author_facet | Seo, Minseok Yoon, Joon Park, Taesung |
author_sort | Seo, Minseok |
collection | PubMed |
description | BACKGROUND: Analysis of large-scale omics data has become more and more challenging due to high dimensionality. More complex analysis methods and tools are required to handle such data. While many methods already exist, those methods often produce different results. To help users obtain more appropriate results (i.e. candidate genes), we propose a tool, GRACOMICS that compares numerous analysis results visually in a more systematic way; this enables the users to easily interpret the results more comfortably. RESULTS: GRACOMICS has the ability to visualize multiple analysis results interactively. We developed GRACOMICS to provide instantaneous results (plots and tables), corresponding to user-defined threshold values, since there are yet no other up-to-date omics data visualization tools that provide such features. In our analysis, we successfully employed two types of omics data: transcriptomic data (microarray and RNA-seq data) and genomic data (SNP chip and NGS data). CONCLUSIONS: GRACOMICS is a graphical user interface (GUI)-based program written in Java for cross-platform computing environments, and can be applied to compare analysis results for any type of large-scale omics data. This tool can be useful for biologists to identify genes commonly found by intersected statistical methods, for further experimental validation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12864-015-1461-0) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-4387734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43877342015-04-08 GRACOMICS: software for graphical comparison of multiple results with omics data Seo, Minseok Yoon, Joon Park, Taesung BMC Genomics Software BACKGROUND: Analysis of large-scale omics data has become more and more challenging due to high dimensionality. More complex analysis methods and tools are required to handle such data. While many methods already exist, those methods often produce different results. To help users obtain more appropriate results (i.e. candidate genes), we propose a tool, GRACOMICS that compares numerous analysis results visually in a more systematic way; this enables the users to easily interpret the results more comfortably. RESULTS: GRACOMICS has the ability to visualize multiple analysis results interactively. We developed GRACOMICS to provide instantaneous results (plots and tables), corresponding to user-defined threshold values, since there are yet no other up-to-date omics data visualization tools that provide such features. In our analysis, we successfully employed two types of omics data: transcriptomic data (microarray and RNA-seq data) and genomic data (SNP chip and NGS data). CONCLUSIONS: GRACOMICS is a graphical user interface (GUI)-based program written in Java for cross-platform computing environments, and can be applied to compare analysis results for any type of large-scale omics data. This tool can be useful for biologists to identify genes commonly found by intersected statistical methods, for further experimental validation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12864-015-1461-0) contains supplementary material, which is available to authorized users. BioMed Central 2015-04-01 /pmc/articles/PMC4387734/ /pubmed/25887412 http://dx.doi.org/10.1186/s12864-015-1461-0 Text en © Seo et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Software Seo, Minseok Yoon, Joon Park, Taesung GRACOMICS: software for graphical comparison of multiple results with omics data |
title | GRACOMICS: software for graphical comparison of multiple results with omics data |
title_full | GRACOMICS: software for graphical comparison of multiple results with omics data |
title_fullStr | GRACOMICS: software for graphical comparison of multiple results with omics data |
title_full_unstemmed | GRACOMICS: software for graphical comparison of multiple results with omics data |
title_short | GRACOMICS: software for graphical comparison of multiple results with omics data |
title_sort | gracomics: software for graphical comparison of multiple results with omics data |
topic | Software |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387734/ https://www.ncbi.nlm.nih.gov/pubmed/25887412 http://dx.doi.org/10.1186/s12864-015-1461-0 |
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