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GRACOMICS: software for graphical comparison of multiple results with omics data

BACKGROUND: Analysis of large-scale omics data has become more and more challenging due to high dimensionality. More complex analysis methods and tools are required to handle such data. While many methods already exist, those methods often produce different results. To help users obtain more appropr...

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Detalles Bibliográficos
Autores principales: Seo, Minseok, Yoon, Joon, Park, Taesung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387734/
https://www.ncbi.nlm.nih.gov/pubmed/25887412
http://dx.doi.org/10.1186/s12864-015-1461-0
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author Seo, Minseok
Yoon, Joon
Park, Taesung
author_facet Seo, Minseok
Yoon, Joon
Park, Taesung
author_sort Seo, Minseok
collection PubMed
description BACKGROUND: Analysis of large-scale omics data has become more and more challenging due to high dimensionality. More complex analysis methods and tools are required to handle such data. While many methods already exist, those methods often produce different results. To help users obtain more appropriate results (i.e. candidate genes), we propose a tool, GRACOMICS that compares numerous analysis results visually in a more systematic way; this enables the users to easily interpret the results more comfortably. RESULTS: GRACOMICS has the ability to visualize multiple analysis results interactively. We developed GRACOMICS to provide instantaneous results (plots and tables), corresponding to user-defined threshold values, since there are yet no other up-to-date omics data visualization tools that provide such features. In our analysis, we successfully employed two types of omics data: transcriptomic data (microarray and RNA-seq data) and genomic data (SNP chip and NGS data). CONCLUSIONS: GRACOMICS is a graphical user interface (GUI)-based program written in Java for cross-platform computing environments, and can be applied to compare analysis results for any type of large-scale omics data. This tool can be useful for biologists to identify genes commonly found by intersected statistical methods, for further experimental validation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12864-015-1461-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-43877342015-04-08 GRACOMICS: software for graphical comparison of multiple results with omics data Seo, Minseok Yoon, Joon Park, Taesung BMC Genomics Software BACKGROUND: Analysis of large-scale omics data has become more and more challenging due to high dimensionality. More complex analysis methods and tools are required to handle such data. While many methods already exist, those methods often produce different results. To help users obtain more appropriate results (i.e. candidate genes), we propose a tool, GRACOMICS that compares numerous analysis results visually in a more systematic way; this enables the users to easily interpret the results more comfortably. RESULTS: GRACOMICS has the ability to visualize multiple analysis results interactively. We developed GRACOMICS to provide instantaneous results (plots and tables), corresponding to user-defined threshold values, since there are yet no other up-to-date omics data visualization tools that provide such features. In our analysis, we successfully employed two types of omics data: transcriptomic data (microarray and RNA-seq data) and genomic data (SNP chip and NGS data). CONCLUSIONS: GRACOMICS is a graphical user interface (GUI)-based program written in Java for cross-platform computing environments, and can be applied to compare analysis results for any type of large-scale omics data. This tool can be useful for biologists to identify genes commonly found by intersected statistical methods, for further experimental validation. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12864-015-1461-0) contains supplementary material, which is available to authorized users. BioMed Central 2015-04-01 /pmc/articles/PMC4387734/ /pubmed/25887412 http://dx.doi.org/10.1186/s12864-015-1461-0 Text en © Seo et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Software
Seo, Minseok
Yoon, Joon
Park, Taesung
GRACOMICS: software for graphical comparison of multiple results with omics data
title GRACOMICS: software for graphical comparison of multiple results with omics data
title_full GRACOMICS: software for graphical comparison of multiple results with omics data
title_fullStr GRACOMICS: software for graphical comparison of multiple results with omics data
title_full_unstemmed GRACOMICS: software for graphical comparison of multiple results with omics data
title_short GRACOMICS: software for graphical comparison of multiple results with omics data
title_sort gracomics: software for graphical comparison of multiple results with omics data
topic Software
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387734/
https://www.ncbi.nlm.nih.gov/pubmed/25887412
http://dx.doi.org/10.1186/s12864-015-1461-0
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