Suppressed autophagy flux in skeletal muscle of an amyotrophic lateral sclerosis mouse model during disease progression

Accumulation of abnormal protein inclusions is implicated in motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Autophagy, an intracellular process targeting misfolded proteins and damaged organelles for lysosomal degradation, plays crucial roles in survival and diseased conditions. E...

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Detalles Bibliográficos
Autores principales: Xiao, Yajuan, Ma, Changling, Yi, Jianxun, Wu, Shaoping, Luo, Guo, Xu, Xiulong, Lin, Pei‐Hui, Sun, Jun, Zhou, Jingsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387765/
https://www.ncbi.nlm.nih.gov/pubmed/25602021
http://dx.doi.org/10.14814/phy2.12271

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