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The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections
Eukaryotic translation elongation factors 1 alpha, eEF1A1 and eEF1A2, are not only translation factors but also pleiotropic proteins that are highly expressed in human tumors, including breast cancer, ovarian cancer, and lung cancer. eEF1A1 modulates cytoskeleton, exhibits chaperone-like activity an...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387925/ https://www.ncbi.nlm.nih.gov/pubmed/25905039 http://dx.doi.org/10.3389/fonc.2015.00075 |
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author | Abbas, Wasim Kumar, Amit Herbein, Georges |
author_facet | Abbas, Wasim Kumar, Amit Herbein, Georges |
author_sort | Abbas, Wasim |
collection | PubMed |
description | Eukaryotic translation elongation factors 1 alpha, eEF1A1 and eEF1A2, are not only translation factors but also pleiotropic proteins that are highly expressed in human tumors, including breast cancer, ovarian cancer, and lung cancer. eEF1A1 modulates cytoskeleton, exhibits chaperone-like activity and also controls cell proliferation and cell death. In contrast, eEF1A2 protein favors oncogenesis as shown by the fact that overexpression of eEF1A2 leads to cellular transformation and gives rise to tumors in nude mice. The eEF1A2 protein stimulates the phospholipid signaling and activates the Akt-dependent cell migration and actin remodeling that ultimately favors tumorigenesis. In contrast, inactivation of eEF1A proteins leads to immunodeficiency, neural and muscular defects, and favors apoptosis. Finally, eEF1A proteins interact with several viral proteins resulting in enhanced viral replication, decreased apoptosis, and increased cellular transformation. This review summarizes the recent findings on eEF1A proteins indicating that eEF1A proteins play a critical role in numerous human diseases through enhancement of oncogenesis, blockade of apoptosis, and increased viral pathogenesis. |
format | Online Article Text |
id | pubmed-4387925 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-43879252015-04-22 The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections Abbas, Wasim Kumar, Amit Herbein, Georges Front Oncol Oncology Eukaryotic translation elongation factors 1 alpha, eEF1A1 and eEF1A2, are not only translation factors but also pleiotropic proteins that are highly expressed in human tumors, including breast cancer, ovarian cancer, and lung cancer. eEF1A1 modulates cytoskeleton, exhibits chaperone-like activity and also controls cell proliferation and cell death. In contrast, eEF1A2 protein favors oncogenesis as shown by the fact that overexpression of eEF1A2 leads to cellular transformation and gives rise to tumors in nude mice. The eEF1A2 protein stimulates the phospholipid signaling and activates the Akt-dependent cell migration and actin remodeling that ultimately favors tumorigenesis. In contrast, inactivation of eEF1A proteins leads to immunodeficiency, neural and muscular defects, and favors apoptosis. Finally, eEF1A proteins interact with several viral proteins resulting in enhanced viral replication, decreased apoptosis, and increased cellular transformation. This review summarizes the recent findings on eEF1A proteins indicating that eEF1A proteins play a critical role in numerous human diseases through enhancement of oncogenesis, blockade of apoptosis, and increased viral pathogenesis. Frontiers Media S.A. 2015-04-07 /pmc/articles/PMC4387925/ /pubmed/25905039 http://dx.doi.org/10.3389/fonc.2015.00075 Text en Copyright © 2015 Abbas, Kumar and Herbein. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Abbas, Wasim Kumar, Amit Herbein, Georges The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections |
title | The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections |
title_full | The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections |
title_fullStr | The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections |
title_full_unstemmed | The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections |
title_short | The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections |
title_sort | eef1a proteins: at the crossroads of oncogenesis, apoptosis, and viral infections |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387925/ https://www.ncbi.nlm.nih.gov/pubmed/25905039 http://dx.doi.org/10.3389/fonc.2015.00075 |
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