Cargando…
Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress
Major depressive disorder (MDD) is a chronic, recurrent, and severe psychiatric disorder with high mortality and medical comorbidities. Stress-related pathways have been directly involved in the pathophysiology and treatment of MDD. The present paper provides an overview on the stress system as a mo...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387963/ https://www.ncbi.nlm.nih.gov/pubmed/25878903 http://dx.doi.org/10.1155/2015/581976 |
_version_ | 1782365354395172864 |
---|---|
author | Gold, Phillip W. Machado-Vieira, Rodrigo Pavlatou, Maria G. |
author_facet | Gold, Phillip W. Machado-Vieira, Rodrigo Pavlatou, Maria G. |
author_sort | Gold, Phillip W. |
collection | PubMed |
description | Major depressive disorder (MDD) is a chronic, recurrent, and severe psychiatric disorder with high mortality and medical comorbidities. Stress-related pathways have been directly involved in the pathophysiology and treatment of MDD. The present paper provides an overview on the stress system as a model to understand key pathophysiological paradigms in MDD. These mechanisms involve behavioral, cognitive, and systemic manifestations and are also associated with the mechanisms of action of effective antidepressants. Aspects such as depression subtypes, inflammation, insulin resistance, oxidative stress, and prothrombotic states in critical brain circuits and periphery are critically appraised. Finally, new strategies for approaching treatment-resistant major depression and potential adverse effects associated with this complex and intricate network are highlighted. The authors used PubMed as the database for this review. Each author extracted relevant data and assessed the methodological quality of each study. |
format | Online Article Text |
id | pubmed-4387963 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43879632015-04-15 Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress Gold, Phillip W. Machado-Vieira, Rodrigo Pavlatou, Maria G. Neural Plast Review Article Major depressive disorder (MDD) is a chronic, recurrent, and severe psychiatric disorder with high mortality and medical comorbidities. Stress-related pathways have been directly involved in the pathophysiology and treatment of MDD. The present paper provides an overview on the stress system as a model to understand key pathophysiological paradigms in MDD. These mechanisms involve behavioral, cognitive, and systemic manifestations and are also associated with the mechanisms of action of effective antidepressants. Aspects such as depression subtypes, inflammation, insulin resistance, oxidative stress, and prothrombotic states in critical brain circuits and periphery are critically appraised. Finally, new strategies for approaching treatment-resistant major depression and potential adverse effects associated with this complex and intricate network are highlighted. The authors used PubMed as the database for this review. Each author extracted relevant data and assessed the methodological quality of each study. Hindawi Publishing Corporation 2015 2015-03-24 /pmc/articles/PMC4387963/ /pubmed/25878903 http://dx.doi.org/10.1155/2015/581976 Text en Copyright © 2015 Phillip W. Gold et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Gold, Phillip W. Machado-Vieira, Rodrigo Pavlatou, Maria G. Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress |
title | Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress |
title_full | Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress |
title_fullStr | Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress |
title_full_unstemmed | Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress |
title_short | Clinical and Biochemical Manifestations of Depression: Relation to the Neurobiology of Stress |
title_sort | clinical and biochemical manifestations of depression: relation to the neurobiology of stress |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387963/ https://www.ncbi.nlm.nih.gov/pubmed/25878903 http://dx.doi.org/10.1155/2015/581976 |
work_keys_str_mv | AT goldphillipw clinicalandbiochemicalmanifestationsofdepressionrelationtotheneurobiologyofstress AT machadovieirarodrigo clinicalandbiochemicalmanifestationsofdepressionrelationtotheneurobiologyofstress AT pavlatoumariag clinicalandbiochemicalmanifestationsofdepressionrelationtotheneurobiologyofstress |