Life-Threatening Hypercalcemia due to Graves' Disease and Concomitant Adrenal Failure: A Case Report and Review of the Literature

A 47-year-old woman presented with the complaints of nausea, vomiting, and weight loss. She had a history of bilateral surrenalectomy due to Cushing's syndrome. On examination she had tachycardia and orthostatic hypotension. Laboratory examinations revealed hypercalcemia and suppressed parathyr...

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Autores principales: Ozkaya, Hande Mefkure, Keskin, Fatma Ela, Haliloglu, Ozlem Asmaz, Senel, Tugba Elif, Kadioglu, Pinar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388017/
https://www.ncbi.nlm.nih.gov/pubmed/25878906
http://dx.doi.org/10.1155/2015/684648
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author Ozkaya, Hande Mefkure
Keskin, Fatma Ela
Haliloglu, Ozlem Asmaz
Senel, Tugba Elif
Kadioglu, Pinar
author_facet Ozkaya, Hande Mefkure
Keskin, Fatma Ela
Haliloglu, Ozlem Asmaz
Senel, Tugba Elif
Kadioglu, Pinar
author_sort Ozkaya, Hande Mefkure
collection PubMed
description A 47-year-old woman presented with the complaints of nausea, vomiting, and weight loss. She had a history of bilateral surrenalectomy due to Cushing's syndrome. On examination she had tachycardia and orthostatic hypotension. Laboratory examinations revealed hypercalcemia and suppressed parathyroid hormone levels. She also had thyrotoxicosis due to Graves' disease. The investigations to rule out a malignancy were negative. With steroid, zoledronic acid, and antithyroid drug treatment her symptoms were resolved and calcium level was normalized. This case highlights the importance of recognizing thyrotoxicosis and concomitant adrenal failure as a possible cause of severe hypercalcemia.
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spelling pubmed-43880172015-04-15 Life-Threatening Hypercalcemia due to Graves' Disease and Concomitant Adrenal Failure: A Case Report and Review of the Literature Ozkaya, Hande Mefkure Keskin, Fatma Ela Haliloglu, Ozlem Asmaz Senel, Tugba Elif Kadioglu, Pinar Case Rep Endocrinol Case Report A 47-year-old woman presented with the complaints of nausea, vomiting, and weight loss. She had a history of bilateral surrenalectomy due to Cushing's syndrome. On examination she had tachycardia and orthostatic hypotension. Laboratory examinations revealed hypercalcemia and suppressed parathyroid hormone levels. She also had thyrotoxicosis due to Graves' disease. The investigations to rule out a malignancy were negative. With steroid, zoledronic acid, and antithyroid drug treatment her symptoms were resolved and calcium level was normalized. This case highlights the importance of recognizing thyrotoxicosis and concomitant adrenal failure as a possible cause of severe hypercalcemia. Hindawi Publishing Corporation 2015 2015-03-24 /pmc/articles/PMC4388017/ /pubmed/25878906 http://dx.doi.org/10.1155/2015/684648 Text en Copyright © 2015 Hande Mefkure Ozkaya et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ozkaya, Hande Mefkure
Keskin, Fatma Ela
Haliloglu, Ozlem Asmaz
Senel, Tugba Elif
Kadioglu, Pinar
Life-Threatening Hypercalcemia due to Graves' Disease and Concomitant Adrenal Failure: A Case Report and Review of the Literature
title Life-Threatening Hypercalcemia due to Graves' Disease and Concomitant Adrenal Failure: A Case Report and Review of the Literature
title_full Life-Threatening Hypercalcemia due to Graves' Disease and Concomitant Adrenal Failure: A Case Report and Review of the Literature
title_fullStr Life-Threatening Hypercalcemia due to Graves' Disease and Concomitant Adrenal Failure: A Case Report and Review of the Literature
title_full_unstemmed Life-Threatening Hypercalcemia due to Graves' Disease and Concomitant Adrenal Failure: A Case Report and Review of the Literature
title_short Life-Threatening Hypercalcemia due to Graves' Disease and Concomitant Adrenal Failure: A Case Report and Review of the Literature
title_sort life-threatening hypercalcemia due to graves' disease and concomitant adrenal failure: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388017/
https://www.ncbi.nlm.nih.gov/pubmed/25878906
http://dx.doi.org/10.1155/2015/684648
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