Antibody-mediated targeting of iron oxide nanoparticles to the folate receptor alpha increases tumor cell association in vitro and in vivo

Active molecular targeting has become an important aspect of nanoparticle development for oncology indications. Here, we describe molecular targeting of iron oxide nanoparticles (IONPs) to the folate receptor alpha (FOLRα) using an engineered antibody fragment (Ffab). Compared to control nanoparticl...

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Detalles Bibliográficos
Autores principales: Ndong, Christian, Toraya-Brown, Seiko, Kekalo, Katsiaryna, Baker, Ian, Gerngross, Tillman U, Fiering, Steven N, Griswold, Karl E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388088/
https://www.ncbi.nlm.nih.gov/pubmed/25878495
http://dx.doi.org/10.2147/IJN.S79367

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