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Structures of the hydrolase domain of zebrafish 10-formyltetrahydrofolate dehydrogenase and its complexes reveal a complete set of key residues for hydrolysis and product inhibition

10-Formyltetrahydrofolate dehydrogenase (FDH), which is composed of a small N-terminal domain (Nt-FDH) and a large C-terminal domain, is an abundant folate enzyme in the liver and converts 10-formyltetrahydrofolate (10-FTHF) to tetrahydrofolate (THF) and CO(2). Nt-FDH alone possesses a hydrolase act...

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Detalles Bibliográficos
Autores principales:	Lin, Chien-Chih, Chuankhayan, Phimonphan, Chang, Wen-Ni, Kao, Tseng-Ting, Guan, Hong-Hsiang, Fun, Hoong-Kun, Nakagawa, Atsushi, Fu, Tzu-Fun, Chen, Chun-Jung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2015
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388273/ https://www.ncbi.nlm.nih.gov/pubmed/25849409 http://dx.doi.org/10.1107/S1399004715002928

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