Cargando…

Myeloperoxidase scavenges peroxynitrite: A novel anti-inflammatory action of the heme enzyme

Peroxynitrite, a potent pro-inflammatory and cytotoxic species, interacts with a variety of heme containing proteins. We addressed the question whether (i) the interaction of myeloperoxidase (MPO, an enzyme generating hypochlorous acid from hydrogen peroxide and chloride ions) with peroxynitrite aff...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koyani, Chintan N., Flemmig, Joerg, Malle, Ernst, Arnhold, Juergen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Academic Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388333/ https://www.ncbi.nlm.nih.gov/pubmed/25731855 http://dx.doi.org/10.1016/j.abb.2015.02.028

Ejemplares similares

Halogenation Activity of Mammalian Heme Peroxidases
por: Arnhold, Jürgen, et al.
Publicado: (2022)

Peroxynitrite-mediated inactivation of heme oxygenases
por: Kinobe, Robert, et al.
Publicado: (2004)

Myeloperoxidase-Derived 2-Chlorohexadecanal Is Generated in Mouse Heart during Endotoxemia and Induces Modification of Distinct Cardiomyocyte Protein Subsets In Vitro
por: Prasch, Jürgen, et al.
Publicado: (2020)

Anti-inflammatory activity of intravenous immunoglobulin through scavenging of heme
por: Wiatr, Marie, et al.
Publicado: (2019)

Gelam Honey Scavenges Peroxynitrite During the Immune Response
por: Kassim, Mustafa, et al.
Publicado: (2012)

Iodide modulates protein damage induced by the inflammation-associated heme enzyme myeloperoxidase
por: Gamon, Luke F., et al.
Publicado: (2019)

Mechanism of reaction of chlorite with mammalian heme peroxidases
por: Jakopitsch, Christa, et al.
Publicado: (2014)

The Dual Role of Myeloperoxidase in Immune Response
por: Arnhold, Jürgen
Publicado: (2020)

Etoposide Reduces Peroxynitrite-Induced Cytotoxicity via Direct Scavenging Effect
por: Choi, In-Young, et al.
Publicado: (2010)

Scavenging of lipid peroxyl radicals protects plasma lipids and proteins from peroxynitrite
por: Mustafa, Ayman G, et al.
Publicado: (2020)

MAPK signaling determines lysophosphatidic acid (LPA)-induced inflammation in microglia
por: Plastira, Ioanna, et al.
Publicado: (2020)

Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ(2)-mediated cell death
por: Koyani, Chintan N., et al.
Publicado: (2016)

The Balancing of Peroxynitrite Detoxification between Ferric Heme-Proteins and CO(2): The Case of Zebrafish Nitrobindin
por: De Simone, Giovanna, et al.
Publicado: (2022)

Behavioral and molecular processing of visceral pain in the brain of mice: impact of colitis and psychological stress
por: Jain, Piyush, et al.
Publicado: (2015)

Peroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chains
por: Kennett, Eleanor C., et al.
Publicado: (2010)

Heme Peroxidases at Unperturbed and Inflamed Mucous Surfaces
por: Arnhold, Jürgen
Publicado: (2021)

Effects of Iron Supplements on Heme Scavengers in Pregnancy
por: Nti, Annette M., et al.
Publicado: (2021)

Plasma marker of tissue oxidative damage and edaravone as a scavenger drug against peroxyl radicals and peroxynitrite
por: Yamamoto, Yorihiro
Publicado: (2017)

Human nitrobindin: the first example of an all‐β‐barrel ferric heme‐protein that catalyzes peroxynitrite detoxification
por: De Simone, Giovanna, et al.
Publicado: (2018)

Amyloid β and free heme: bloody new insights into the pathogenesis of Alzheimer’s disease
por: Flemmig, Jörg, et al.
Publicado: (2018)

I(f) blocking potency of ivabradine is preserved under elevated endotoxin levels in human atrial myocytes
por: Scheruebel, Susanne, et al.
Publicado: (2014)

Heme Scavenging and Delivery: The Role of Human Serum Albumin
por: De Simone, Giovanna, et al.
Publicado: (2023)

15-deoxy-Δ(12,14)-PGJ(2) promotes inflammation and apoptosis in cardiomyocytes via the DP2/MAPK/TNFα axis
por: Koyani, Chintan N., et al.
Publicado: (2014)

β‐catenin regulates FOXP2 transcriptional activity via multiple binding sites
por: Richter, Gesa, et al.
Publicado: (2020)

Root Bark of Paeonia suffruticosa Extract and Its Component Methyl Gallate Possess Peroxynitrite Scavenging Activity and Anti-Inflammatory Properties through NF-κB Inhibition in LPS-treated Mice
por: Park, Dong Jin, et al.
Publicado: (2019)

Myeloperoxidase-Derived Oxidants Induce Blood-Brain Barrier Dysfunction In Vitro and In Vivo
por: Üllen, Andreas, et al.
Publicado: (2013)

Comparison of Hydroxyl Radical, Peroxyl Radical, and Peroxynitrite Scavenging Capacity of Extracts and Active Components from Selected Medicinal Plants
por: Kwon, Do Young, et al.
Publicado: (2010)

Targeted subendothelial matrix oxidation by myeloperoxidase triggers myosin II-dependent de-adhesion and alters signaling in endothelial cells
por: Rees, Martin D., et al.
Publicado: (2012)

Peroxynitrite induced cytotoxicity and detection in cardiovascular, neurodegenerative and inflammatory disorders
por: Ahmad, Rizwan
Publicado: (2022)

Chlorination and oxidation of the extracellular matrix protein laminin and basement membrane extracts by hypochlorous acid and myeloperoxidase
por: Nybo, Tina, et al.
Publicado: (2018)

Myeloid expression of the anti-apoptotic protein Mcl1 is required in anti-myeloperoxidase vasculitis but myeloperoxidase inhibition is not protective
por: Florez-Barros, Fernanda, et al.
Publicado: (2023)

Myeloperoxidase-Oxidized LDL Activates Human Aortic Endothelial Cells through the LOX-1 Scavenger Receptor
por: El-Hajjar, Layal, et al.
Publicado: (2022)

Melatonin Prevents Myeloperoxidase Heme Destruction and the Generation of Free Iron Mediated by Self-Generated Hypochlorous Acid
por: Shaeib, Faten, et al.
Publicado: (2015)

Hypochlorite-Modified LDL Induces Arrhythmia and Contractile Dysfunction in Cardiomyocytes
por: Koyani, Chintan N., et al.
Publicado: (2021)

Cell signaling and cytotoxicity by peroxynitrite.
por: Cantoni, Orazio, et al.
Publicado: (2002)

Modulation of myocardial contraction by peroxynitrite
por: Kohr, Mark J., et al.
Publicado: (2012)

Association of myeloperoxidase with total and cardiovascular mortality in individuals undergoing coronary angiography—The LURIC study
por: Scharnagl, Hubert, et al.
Publicado: (2014)

Cyclooxygenase-2 Glycosylation Is Affected by Peroxynitrite in Endothelial Cells: Impact on Enzyme Activity and Degradation
por: Eligini, Sonia, et al.
Publicado: (2021)

The Haptoglobin-CD163-Heme Oxygenase-1 Pathway for Hemoglobin Scavenging
por: Thomsen, Jens Haugbølle, et al.
Publicado: (2013)

Exogenously Scavenged and Endogenously Synthesized Heme Are Differentially Utilized by Mycobacterium tuberculosis
por: Donegan, Rebecca K., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_t35it34c86orbih3ncdtnhlmf2