Cargando…

Ketones Prevent Oxidative Impairment of Hippocampal Synaptic Integrity through K(ATP) Channels

Dietary and metabolic therapies are increasingly being considered for a variety of neurological disorders, based in part on growing evidence for the neuroprotective properties of the ketogenic diet (KD) and ketones. Earlier, we demonstrated that ketones afford hippocampal synaptic protection against...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Do Young, Abdelwahab, Mohammed G., Lee, Soo Han, O’Neill, Derek, Thompson, Roger J., Duff, Henry J., Sullivan, Patrick G., Rho, Jong M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388385/ https://www.ncbi.nlm.nih.gov/pubmed/25848768 http://dx.doi.org/10.1371/journal.pone.0119316

Ejemplares similares

Ketones prevent synaptic dysfunction induced by mitochondrial respiratory complex inhibitors
por: Kim, Do Young, et al.
Publicado: (2010)

How ATP Inhibits the Open K(ATP) Channel
por: Craig, Tim J., et al.
Publicado: (2008)

The dynamic interplay of PIP(2) and ATP in the regulation of the K(ATP) channel
por: Pipatpolkai, Tanadet, et al.
Publicado: (2022)

ATP11B deficiency leads to impairment of hippocampal synaptic plasticity
por: Wang, Jiao, et al.
Publicado: (2019)

Molecular Analysis of ATP-sensitive K Channel Gating and Implications for Channel Inhibition by ATP
por: Trapp, Stefan, et al.
Publicado: (1998)

Octameric Stoichiometry of the K(ATP) Channel Complex
por: Shyng, S.-L., et al.
Publicado: (1997)

Central K(ATP) Channels Modulate Glucose Effectiveness in Humans and Rodents
por: Carey, Michelle, et al.
Publicado: (2020)

Evidence for a K(ATP) Channel in Rough Endoplasmic Reticulum (rerK(ATP) Channel) of Rat Hepatocytes
por: Salari, Sajjad, et al.
Publicado: (2015)

Gating Mechanism of K(ATP) Channels: Function Fits Form
por: Enkvetchakul, D., et al.
Publicado: (2003)

R-type voltage-gated Ca(2+) channels mediate A-type K(+) current regulation of synaptic input in hippocampal dendrites
por: Murphy, Jonathan G., et al.
Publicado: (2022)

Cardiovascular K(ATP) channels and advanced aging
por: Yang, Hua-Qian, et al.
Publicado: (2016)

K(ATP) Channel Mutations and Neonatal Diabetes
por: Shimomura, Kenju, et al.
Publicado: (2017)

ATP-sensitive potassium channel (K(ATP )channel) expression in the normal canine pancreas and in canine insulinomas
por: Donley, Vicky R, et al.
Publicado: (2005)

ATP and Sulfonylurea Linkage in the K(ATP) Channel Solves a Diabetes Puzzler
por: Drain, Peter
Publicado: (2013)

Sulfonylurea and K(+)-Channel Opener Sensitivity of K(ATP) Channels: Functional Coupling of Kir6.2 and Sur1 Subunits
por: Koster, J.C., et al.
Publicado: (1999)

Ketone Administration for Seizure Disorders: History and Rationale for Ketone Esters and Metabolic Alternatives
por: Poff, Angela M., et al.
Publicado: (2019)

Mice expressing a human K(ATP) channel mutation have altered channel ATP sensitivity but no cardiac abnormalities
por: Clark, R., et al.
Publicado: (2012)

Targeting ATP-Sensitive K(+) Channels to Treat Pulmonary Hypertension
por: Breen, Ellen, et al.
Publicado: (2022)

Mechanism of ATP-sensitive K Channel Inhibition by Sulfhydryl Modification
por: Trapp, Stefan, et al.
Publicado: (1998)

The Downregulation of Somatic A-Type K(+) Channels Requires the Activation of Synaptic NMDA Receptors in Young Hippocampal Neurons of Rats
por: Kang, Moon-Seok, et al.
Publicado: (2014)

Ketone Bodies Inhibit the Opening of Acid-Sensing Ion Channels (ASICs) in Rat Hippocampal Excitatory Neurons in vitro
por: Zhu, Fei, et al.
Publicado: (2019)

Upregulation of an inward rectifying K(+) channel can rescue slow Ca(2+) oscillations in K(ATP) channel deficient pancreatic islets
por: Yildirim, Vehpi, et al.
Publicado: (2017)

Inhibition of Hippocampal Synaptic Activity by ATP, Hypoxia or Oxygen-Glucose Deprivation Does Not Require CD73
por: Zhang, Dali, et al.
Publicado: (2012)

The unusual stoichiometry of ADP activation of the K(ATP) channel
por: Hosy, Eric, et al.
Publicado: (2014)

K(ATP) channel dependent heart multiome atlas
por: Arrell, D. Kent, et al.
Publicado: (2022)

Ligand-dependent Linkage of the ATP Site to Inhibition Gate Closure in the K(ATP) Channel
por: Li, Lehong, et al.
Publicado: (2005)

Open State Destabilization by Atp Occupancy Is Mechanism Speeding Burst Exit Underlying K(ATP) Channel Inhibition by Atp
por: Li, Lehong, et al.
Publicado: (2002)

Increase of ATP-sensitive potassium (K(ATP)) channels in the heart of type-1 diabetic rats
por: Chen, Zhih-Cherng, et al.
Publicado: (2012)

The ATP sensitive potassium channel (K(ATP)) is a novel target for migraine drug development
por: Clement, Amalie, et al.
Publicado: (2023)

Structural Determinants of Pip(2) Regulation of Inward Rectifier K(ATP) Channels
por: Shyng, Show-Ling, et al.
Publicado: (2000)

Surface charge and properties of cardiac ATP-sensitive K+ channels
Publicado: (1994)

Neonatal Diabetes and the K(ATP) Channel: From Mutation to Therapy
por: Ashcroft, Frances M., et al.
Publicado: (2017)

The role of K(ATP) channels in cerebral ischemic stroke and diabetes
por: Szeto, Vivian, et al.
Publicado: (2018)

Localization of ATP-sensitive K(+) channel subunits in rat liver
por: Zhou, Ming, et al.
Publicado: (2019)

K(ATP) Channel Function: More than Meets the Eye
por: Shyng, Show-Ling
Publicado: (2022)

ApoE isoform-dependent changes in hippocampal synaptic function
por: Korwek, Kimberly M, et al.
Publicado: (2009)

Phosphoinositides Decrease Atp Sensitivity of the Cardiac Atp-Sensitive K(+) Channel: A Molecular Probe for the Mechanism of Atp-Sensitive Inhibition
por: Fan, Zheng, et al.
Publicado: (1999)

Ligand-insensitive State of Cardiac ATP-sensitive K(+) Channels : Basis for Channel Opening
por: Alekseev, Alexey E., et al.
Publicado: (1998)

Control of Rectification and Gating of Cloned K(ATP) Channels by the Kir6.2 Subunit
por: Shyng, S.-L., et al.
Publicado: (1997)

Activation of the mitochondrial ATP-sensitive K(+) channel reduces apoptosis of spleen mononuclear cells induced by hyperlipidemia
por: Alberici, Luciane C, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_jhlr4i4i0707cl1jaa15g36hat