Comprehensive Profiling of Amino Acid Response Uncovers Unique Methionine-Deprived Response Dependent on Intact Creatine Biosynthesis

Besides being building blocks for protein synthesis, amino acids serve a wide variety of cellular functions, including acting as metabolic intermediates for ATP generation and for redox homeostasis. Upon amino acid deprivation, free uncharged tRNAs trigger GCN2-ATF4 to mediate the well-characterized...

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Detalles Bibliográficos
Autores principales: Tang, Xiaohu, Keenan, Melissa M., Wu, Jianli, Lin, Chih-An, Dubois, Laura, Thompson, J. Will, Freedland, Stephen J., Murphy, Susan K., Chi, Jen-Tsan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388453/
https://www.ncbi.nlm.nih.gov/pubmed/25849282
http://dx.doi.org/10.1371/journal.pgen.1005158

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