Cargando…

Genomic Heterogeneity of Osteosarcoma - Shift from Single Candidates to Functional Modules

Osteosarcoma (OS), a bone tumor, exhibit a complex karyotype. On the genomic level a highly variable degree of alterations in nearly all chromosomal regions and between individual tumors is observable. This hampers the identification of common drivers in OS biology. To identify the common molecular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Poos, Kathrin, Smida, Jan, Maugg, Doris, Eckstein, Gertrud, Baumhoer, Daniel, Nathrath, Michaela, Korsching, Eberhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388529/ https://www.ncbi.nlm.nih.gov/pubmed/25848766 http://dx.doi.org/10.1371/journal.pone.0123082

Ejemplares similares

How MicroRNA and Transcription Factor Co-regulatory Networks Affect Osteosarcoma Cell Proliferation
por: Poos, Kathrin, et al.
Publicado: (2013)

Structuring osteosarcoma knowledge: an osteosarcoma-gene association database based on literature mining and manual annotation
por: Poos, Kathrin, et al.
Publicado: (2014)

New Small Molecules Targeting Apoptosis and Cell Viability in Osteosarcoma
por: Maugg, Doris, et al.
Publicado: (2015)

The long non-coding RNA PARTICLE is associated with WWOX and the absence of FRA16D breakage in osteosarcoma patients
por: O'Leary, Valerie Bríd, et al.
Publicado: (2017)

Upregulation of the miR-17-92 cluster and its two paraloga in osteosarcoma – reasons and consequences
por: Arabi, Leila, et al.
Publicado: (2014)

CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patients
por: Baumhoer, Daniel, et al.
Publicado: (2011)

Osteosarcoma cells with genetic signatures of BRCAness are susceptible to the PARP inhibitor talazoparib alone or in combination with chemotherapeutics
por: Engert, Florian, et al.
Publicado: (2016)

Overactivation of the IGF signalling pathway in osteosarcoma: a potential therapeutic target?
por: Ameline, Baptiste, et al.
Publicado: (2020)

NTRK fusions in osteosarcoma are rare and non‐functional events
por: Ameline, Baptiste, et al.
Publicado: (2020)

DNA methylation-based classifier and gene expression signatures detect BRCAness in osteosarcoma
por: Barenboim, Maxim, et al.
Publicado: (2021)

Solitary pulmonary metastases at first recurrence of osteosarcoma: Presentation, treatment, and survival of 219 patients of the Cooperative Osteosarcoma Study Group
por: Mettmann, Vanessa L., et al.
Publicado: (2023)

The early evolutionary landscape of osteosarcoma provides clues for targeted treatment strategies
por: Kovac, Michal, et al.
Publicado: (2021)

Secondary Radiation-Induced Bone Tumours Demonstrate a High Degree of Genomic Instability Predictive of a Poor Prognosis
por: Rümenapp, Christine, et al.
Publicado: (2012)

Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency
por: Kovac, Michal, et al.
Publicado: (2015)

TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome
por: Ribi, Sebastian, et al.
Publicado: (2015)

Long non-coding RNA PARTICLE bridges histone and DNA methylation
por: O’Leary, Valerie Bríd, et al.
Publicado: (2017)

Allelic Imbalances in Radiation—Associated Acute Myeloid Leukemia
por: Klymenko, Sergiy V., et al.
Publicado: (2011)

A complex pattern of chemokine receptor expression is seen in osteosarcoma
por: von Luettichau, Irene, et al.
Publicado: (2008)

Report from the 4th European Bone Sarcoma Networking meeting: focus on osteosarcoma
por: Strauss, Sandra J., et al.
Publicado: (2018)

Pseudocystic Osteosarcoma: A Potential Diagnostic Pitfall - Case Report
por: Abcha, Oussama, et al.
Publicado: (2021)

A Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated mice
por: Rosemann, Michael, et al.
Publicado: (2014)

PARTICLE triplexes cluster in the tumor suppressor WWOX and may extend throughout the human genome
por: O’Leary, Valerie Bríd, et al.
Publicado: (2017)

Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma
por: Zhou, Yan, et al.
Publicado: (2020)

Splice variants denote differences between a cancer stem cell side population of EWSR1-ERG-based Ewing sarcoma cells, its main population and EWSR1-FLI-based cells
por: Korsching, Eberhard, et al.
Publicado: (2022)

Methylation and copy number profiling: emerging tools to differentiate osteoblastoma from malignant mimics?
por: Ameline, Baptiste, et al.
Publicado: (2022)

Abnormal signal pathways and tumor heterogeneity in osteosarcoma
por: Sun, Yifeng, et al.
Publicado: (2023)

Single-photon frequency shifting with a quadrature phase-shift keying modulator
por: Chen, Changchen, et al.
Publicado: (2021)

Osteosarcoma of the Mandible in a Patient with Florid Cemento-Osseous Dysplasia and Li–Fraumeni Syndrome: A Rare Coincidence
por: Haefliger, Simon, et al.
Publicado: (2020)

Author Correction: Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma
por: Zhou, Yan, et al.
Publicado: (2021)

SHIFT: heterogeneous workstation services at CERN
por: Lee, G, et al.
Publicado: (1993)

Single-cell RNA sequencing reveals the cellular and molecular heterogeneity of treatment-naïve primary osteosarcoma in dogs
por: Ammons, Dylan, et al.
Publicado: (2023)

Identification of candidate neoantigens produced by fusion transcripts in human osteosarcomas
por: Rathe, Susan K., et al.
Publicado: (2019)

Niclosamide is a potential candidate for the treatment of chemo-resistant osteosarcoma
por: Huang, Xiaoling, et al.
Publicado: (2023)

TMAinspiration: Decode Interdependencies in Multifactorial Tissue Microarray Data
por: Boecker, Florian, et al.
Publicado: (2016)

High-Grade Osteosarcoma of the Foot: Presentation, Treatment, Prognostic Factors, and Outcome of 23 Cooperative Osteosarcoma Study Group COSS Patients
por: Schuster, Anne J., et al.
Publicado: (2018)

Heterogeneity of Osteosarcoma Cell Lines Led to Variable Responses in Reprogramming
por: Choong, Pei Feng, et al.
Publicado: (2014)

The Heterogeneity of Infiltrating Macrophages in Metastatic Osteosarcoma and Its Correlation with Immunotherapy
por: Wang, Zhanchao, et al.
Publicado: (2021)

Modeling phenotypic heterogeneity towards evolutionarily inspired osteosarcoma therapy
por: Welch, Darcy L., et al.
Publicado: (2023)

Novel application of single-cell next-generation sequencing for determination of intratumoral heterogeneity of canine osteosarcoma cell lines
por: Ayers, Jordan, et al.
Publicado: (2021)

Single-Cell Profiling of Tumor Microenvironment Heterogeneity in Osteosarcoma Identifies a Highly Invasive Subcluster for Predicting Prognosis
por: Guo, Junfeng, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9e1e6u1v64sasbe3c03j1120o2