The Amelioration of Hepatic Steatosis by Thyroid Hormone Receptor Agonists Is Insufficient to Restore Insulin Sensitivity in Ob/Ob Mice

Thyroid hormone receptor (TR) agonists have been proposed as therapeutic agents to treat non-alcoholic fatty liver disease (NAFLD) and insulin resistance. We investigated the ability of the TR agonists GC-1 and KB2115 to reduce hepatic steatosis in ob/ob mice. Both compounds markedly reduced hepatic...

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Detalles Bibliográficos
Autores principales: Martagón, Alexandro J., Lin, Jean Z., Cimini, Stephanie L., Webb, Paul, Phillips, Kevin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388544/
https://www.ncbi.nlm.nih.gov/pubmed/25849936
http://dx.doi.org/10.1371/journal.pone.0122987

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