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Chromatin Function Modifying Elements in an Industrial Antibody Production Platform - Comparison of UCOE, MAR, STAR and cHS4 Elements

The isolation of stably transfected cell lines suitable for the manufacture of biotherapeutic protein products can be an arduous process relying on the identification of a high expressing clone; this frequently involves transgene amplification and maintenance of the clones’ expression over at least...

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Detalles Bibliográficos
Autores principales: Saunders, Fay, Sweeney, Berni, Antoniou, Michael N., Stephens, Paul, Cain, Katharine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388700/
https://www.ncbi.nlm.nih.gov/pubmed/25849659
http://dx.doi.org/10.1371/journal.pone.0120096

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