Cargando…

Dual Targeted Therapy with p53 siRNA and Epigallocatechingallate in a Triple Negative Breast Cancer Cell Model

Triple-negative breast cancer (TNBC) is a highly aggressive phenotype that is resistant to standard therapy. Thus, the development of alternative therapeutic strategies for TNBC is essential. The purpose of our in vitro study was to evaluate the impact of p53 gene silencing in conjunction with the a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Braicu, Cornelia, Pileczki, Valentina, Pop, Laura, Petric, Roxana Cojocneanu, Chira, Sergiu, Pointiere, Eve, Achimas-Cadariu, Patriciu, Berindan-Neagoe, Ioana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388814/ https://www.ncbi.nlm.nih.gov/pubmed/25849487 http://dx.doi.org/10.1371/journal.pone.0120936

Ejemplares similares

p53 siRNA - a therapeutic tool with significant implication in the modulation of apoptosis and angiogenic pathways
por: BRAICU, OVIDIU, et al.
Publicado: (2015)

Clinical and pathological implications of miRNA in bladder cancer
por: Braicu, Cornelia, et al.
Publicado: (2015)

Normalization of gene expression measurement of tissue samples obtained by transurethral resection of bladder tumors
por: Pop, Laura A, et al.
Publicado: (2016)

Premature senescence activation in DLD-1 colorectal cancer cells through adjuvant therapy to induce a miRNA profile modulating cellular death
por: Chira, Sergiu, et al.
Publicado: (2018)

Comprehensive Analysis of the Expression of Key Genes Related to Hippo Signaling and Their Prognosis Impact in Ovarian Cancer
por: Kubelac, Paul, et al.
Publicado: (2021)

Aberrant miRNAs expressed in HER-2 negative breast cancers patient
por: Braicu, Cornelia, et al.
Publicado: (2018)

Evaluation of cellular and molecular impact of zearalenone and Escherichia coli co-exposure on IPEC-1 cells using microarray technology
por: Braicu, Cornelia, et al.
Publicado: (2016)

Double gene siRNA knockdown of mutant p53 and TNF induces apoptosis in triple-negative breast cancer cells
por: Pileczki, Valentina, et al.
Publicado: (2016)

miRNA expression profiling in formalin-fixed paraffin-embedded endometriosis and ovarian cancer samples
por: Braicu, Ovidiu-Leonard, et al.
Publicado: (2017)

Cancer-Associated Stemness and Epithelial-to-Mesenchymal Transition Signatures Related to Breast Invasive Carcinoma Prognostic
por: Groza, Iulia-Monica, et al.
Publicado: (2020)

Understanding the Role of Non-Coding RNAs in Bladder Cancer: From Dark Matter to Valuable Therapeutic Targets
por: Pop-Bica, Cecilia, et al.
Publicado: (2017)

MicroRNAs as regulators of apoptosis mechanisms in cancer
por: PILECZKI, VALENTINA, et al.
Publicado: (2016)

TNF-α Gene Knockout in Triple Negative Breast Cancer Cell Line Induces Apoptosis
por: Pileczki, Valentina, et al.
Publicado: (2012)

Investigating Circular RNAs Using qRT-PCR; Roundup of Optimization and Processing Steps
por: Drula, Rares, et al.
Publicado: (2023)

Evolutionary perspectives, heterogeneity and ovarian cancer: a complicated tale from past to present
por: Achimas-Cadariu, Patriciu, et al.
Publicado: (2022)

Combining the chemotherapeutic effects of epigallocatechin 3-gallate with siRNA-mediated p53 knock-down results in synergic pro-apoptotic effects
por: Berindan-Neagoe, Ioana, et al.
Publicado: (2012)

Interspecies Gene Name Extrapolation—A New Approach
por: Petric, Roxana Cojocneanu, et al.
Publicado: (2015)

Phytochemicals modulate carcinogenic signaling pathways in breast and hormone-related cancers
por: Cojocneanu Petric, Roxana, et al.
Publicado: (2015)

Microarray based gene expression analysis of Sus Scrofa duodenum exposed to zearalenone: significance to human health
por: Braicu, Cornelia, et al.
Publicado: (2016)

Connecting the dots between different networks: miRNAs associated with bladder cancer risk and progression
por: Braicu, Cornelia, et al.
Publicado: (2019)

Gene Expression Patterns Unveil New Insights in Papillary Thyroid Cancer
por: Saftencu, Mihai, et al.
Publicado: (2019)

Implications of dietary ω-3 and ω-6 polyunsaturated fatty acids in breast cancer
por: Zanoaga, Oana, et al.
Publicado: (2018)

The Connection between MicroRNAs and Oral Cancer Pathogenesis: Emerging Biomarkers in Oral Cancer Management
por: Osan, Ciprian, et al.
Publicado: (2021)

Role of Key Micronutrients from Nutrigenetic and Nutrigenomic Perspectives in Cancer Prevention
por: Irimie, Alexandra Iulia, et al.
Publicado: (2019)

Next generation sequencing applications for breast cancer research
por: PETRIC, ROXANA COJOCNEANU, et al.
Publicado: (2015)

A Looking-Glass of Non-Coding RNAs in Oral Cancer
por: Irimie, Alexandra Iulia, et al.
Publicado: (2017)

miR‐181a/b therapy in lung cancer: reality or myth?
por: Braicu, Cornelia, et al.
Publicado: (2019)

Identification of Core Genes Involved in the Progression of Cervical Cancer Using an Integrative mRNA Analysis
por: Dudea-Simon, Marina, et al.
Publicado: (2020)

PSA Based Biomarkers, Imagistic Techniques and Combined Tests for a Better Diagnostic of Localized Prostate Cancer
por: Munteanu, Vlad Cristian, et al.
Publicado: (2020)

Prognostic Value of MiR-21: An Updated Meta-Analysis in Head and Neck Squamous Cell Carcinoma (HNSCC)
por: Irimie-Aghiorghiesei, Alexandra Iulia, et al.
Publicado: (2019)

Small molecules against B-RAF (BRAF) Val600Glu (V600E) single mutation
por: Zaharie, Florin, et al.
Publicado: (2015)

Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis and autophagy in oral cancer SSC-4 cells
por: Irimie, Alexandra Iulia, et al.
Publicado: (2015)

Dietary Intervention by Phytochemicals and Their Role in Modulating Coding and Non-Coding Genes in Cancer
por: Budisan, Liviuta, et al.
Publicado: (2017)

Targeting Cell Death Mechanism Specifically in Triple Negative Breast Cancer Cell Lines
por: Pruteanu, Lavinia-Lorena, et al.
Publicado: (2022)

Differential Effect of Smoking on Gene Expression in Head and Neck Cancer Patients
por: Irimie, Alexandra Iulia, et al.
Publicado: (2018)

Genome Editing Approaches with CRISPR/Cas9 for Cancer Treatment: Critical Appraisal of Preclinical and Clinical Utility, Challenges, and Future Research
por: Chira, Sergiu, et al.
Publicado: (2022)

The role of medical registries, potential applications and limitations
por: Pop, Bogdan, et al.
Publicado: (2019)

New insights in gene expression alteration as effect of doxorubicin drug resistance in triple negative breast cancer cells
por: Ciocan-Cartita, Cristina Alexandra, et al.
Publicado: (2020)

Correction to: New insights in gene expression alteration as effect of doxorubicin drug resistance in triple negative breast cancer cells
por: Ciocan-Cartita, Cristina Alexandra, et al.
Publicado: (2020)

Discovering the Biological Significance and Therapeutic Potential of miR-29b-3p in Triple-Negative Breast Cancer
por: Jurj, Ancuta, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_i70li35khb1j0opubho9tesnr0