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Induction of Size-Dependent Breakdown of Blood-Milk Barrier in Lactating Mice by TiO(2) Nanoparticles
This study aims to investigate the potential nanotoxic effects of TiO(2) nanoparticles (TNPs) to dams and pups during lactation period. TiO(2) nanoparticles are accumulated in mammary glands of lactating mice after i.v. administration. This accumulation of TiO(2) NP likely causes a ROS-induced disru...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388820/ https://www.ncbi.nlm.nih.gov/pubmed/25849145 http://dx.doi.org/10.1371/journal.pone.0122591 |
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author | Zhang, Chengke Zhai, Shumei Wu, Ling Bai, Yuhong Jia, Jianbo Zhang, Yi Zhang, Bin Yan, Bing |
author_facet | Zhang, Chengke Zhai, Shumei Wu, Ling Bai, Yuhong Jia, Jianbo Zhang, Yi Zhang, Bin Yan, Bing |
author_sort | Zhang, Chengke |
collection | PubMed |
description | This study aims to investigate the potential nanotoxic effects of TiO(2) nanoparticles (TNPs) to dams and pups during lactation period. TiO(2) nanoparticles are accumulated in mammary glands of lactating mice after i.v. administration. This accumulation of TiO(2) NP likely causes a ROS-induced disruption of tight junction of the blood-milk barrier as indicated by the loss of tight junction proteins and the shedding of alveolar epithelial cells. Compared to larger TNPs (50 nm), smaller ones (8 nm) exhibit a higher accumulation in mammary glands and are more potent in causing perturbations to blood-milk barrier. An alarming finding is that the smaller TNPs (8 nm) are transferred from dams to pups through breastfeeding, likely through the disrupted blood-milk barrier. However, during the lactation period, the nutrient quality of milk from dams and the early developmental landmarks of the pups are not affected by above perturbations. |
format | Online Article Text |
id | pubmed-4388820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-43888202015-04-21 Induction of Size-Dependent Breakdown of Blood-Milk Barrier in Lactating Mice by TiO(2) Nanoparticles Zhang, Chengke Zhai, Shumei Wu, Ling Bai, Yuhong Jia, Jianbo Zhang, Yi Zhang, Bin Yan, Bing PLoS One Research Article This study aims to investigate the potential nanotoxic effects of TiO(2) nanoparticles (TNPs) to dams and pups during lactation period. TiO(2) nanoparticles are accumulated in mammary glands of lactating mice after i.v. administration. This accumulation of TiO(2) NP likely causes a ROS-induced disruption of tight junction of the blood-milk barrier as indicated by the loss of tight junction proteins and the shedding of alveolar epithelial cells. Compared to larger TNPs (50 nm), smaller ones (8 nm) exhibit a higher accumulation in mammary glands and are more potent in causing perturbations to blood-milk barrier. An alarming finding is that the smaller TNPs (8 nm) are transferred from dams to pups through breastfeeding, likely through the disrupted blood-milk barrier. However, during the lactation period, the nutrient quality of milk from dams and the early developmental landmarks of the pups are not affected by above perturbations. Public Library of Science 2015-04-07 /pmc/articles/PMC4388820/ /pubmed/25849145 http://dx.doi.org/10.1371/journal.pone.0122591 Text en © 2015 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Zhang, Chengke Zhai, Shumei Wu, Ling Bai, Yuhong Jia, Jianbo Zhang, Yi Zhang, Bin Yan, Bing Induction of Size-Dependent Breakdown of Blood-Milk Barrier in Lactating Mice by TiO(2) Nanoparticles |
title | Induction of Size-Dependent Breakdown of Blood-Milk Barrier in Lactating Mice by TiO(2) Nanoparticles |
title_full | Induction of Size-Dependent Breakdown of Blood-Milk Barrier in Lactating Mice by TiO(2) Nanoparticles |
title_fullStr | Induction of Size-Dependent Breakdown of Blood-Milk Barrier in Lactating Mice by TiO(2) Nanoparticles |
title_full_unstemmed | Induction of Size-Dependent Breakdown of Blood-Milk Barrier in Lactating Mice by TiO(2) Nanoparticles |
title_short | Induction of Size-Dependent Breakdown of Blood-Milk Barrier in Lactating Mice by TiO(2) Nanoparticles |
title_sort | induction of size-dependent breakdown of blood-milk barrier in lactating mice by tio(2) nanoparticles |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388820/ https://www.ncbi.nlm.nih.gov/pubmed/25849145 http://dx.doi.org/10.1371/journal.pone.0122591 |
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