Skin CD30(+) T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease

OBJECTIVE: To determine serum soluble CD30 (sCD30) levels in patients with graft versus host disease (GVHD). METHODS: Serum soluble CD30 levels and IgE levels were assayed by a sensitive ELISA in 57 patients with bone marrow transplantation, and in 44 healthy controls. We analyzed the type of effect...

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Autores principales: Amedei, Amedeo, Pimpinelli, Nicola, Grassi, Alessia, Bella, Chiara Della, Niccolai, Elena, Brancati, Simona, Benagiano, Marisa, D’Elios, Sofia, Bosi, Alberto, D’Elios, Mario M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389013/
https://www.ncbi.nlm.nih.gov/pubmed/26000151
http://dx.doi.org/10.1007/s13317-013-0054-7
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author Amedei, Amedeo
Pimpinelli, Nicola
Grassi, Alessia
Bella, Chiara Della
Niccolai, Elena
Brancati, Simona
Benagiano, Marisa
D’Elios, Sofia
Bosi, Alberto
D’Elios, Mario M.
author_facet Amedei, Amedeo
Pimpinelli, Nicola
Grassi, Alessia
Bella, Chiara Della
Niccolai, Elena
Brancati, Simona
Benagiano, Marisa
D’Elios, Sofia
Bosi, Alberto
D’Elios, Mario M.
author_sort Amedei, Amedeo
collection PubMed
description OBJECTIVE: To determine serum soluble CD30 (sCD30) levels in patients with graft versus host disease (GVHD). METHODS: Serum soluble CD30 levels and IgE levels were assayed by a sensitive ELISA in 57 patients with bone marrow transplantation, and in 44 healthy controls. We analyzed the type of effector T cells in patients with GVHD. RESULTS: Serum levels of sCD30 and serum IgE levels were significantly higher (p values <0.05) in patients with acute and chronic GVHD than in healthy controls. We found that CD30(+) T-cells are present in the skin of patients with GVHD. CONCLUSION: These results suggest that serum sCD30 levels may be helpful for the management of patients with bone marrow transplantation.
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spelling pubmed-43890132015-05-21 Skin CD30(+) T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease Amedei, Amedeo Pimpinelli, Nicola Grassi, Alessia Bella, Chiara Della Niccolai, Elena Brancati, Simona Benagiano, Marisa D’Elios, Sofia Bosi, Alberto D’Elios, Mario M. Auto Immun Highlights Original Article OBJECTIVE: To determine serum soluble CD30 (sCD30) levels in patients with graft versus host disease (GVHD). METHODS: Serum soluble CD30 levels and IgE levels were assayed by a sensitive ELISA in 57 patients with bone marrow transplantation, and in 44 healthy controls. We analyzed the type of effector T cells in patients with GVHD. RESULTS: Serum levels of sCD30 and serum IgE levels were significantly higher (p values <0.05) in patients with acute and chronic GVHD than in healthy controls. We found that CD30(+) T-cells are present in the skin of patients with GVHD. CONCLUSION: These results suggest that serum sCD30 levels may be helpful for the management of patients with bone marrow transplantation. Springer International Publishing 2013-08-31 /pmc/articles/PMC4389013/ /pubmed/26000151 http://dx.doi.org/10.1007/s13317-013-0054-7 Text en © Springer-Verlag Italia 2013
spellingShingle Original Article
Amedei, Amedeo
Pimpinelli, Nicola
Grassi, Alessia
Bella, Chiara Della
Niccolai, Elena
Brancati, Simona
Benagiano, Marisa
D’Elios, Sofia
Bosi, Alberto
D’Elios, Mario M.
Skin CD30(+) T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease
title Skin CD30(+) T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease
title_full Skin CD30(+) T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease
title_fullStr Skin CD30(+) T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease
title_full_unstemmed Skin CD30(+) T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease
title_short Skin CD30(+) T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease
title_sort skin cd30(+) t cells and circulating levels of soluble cd30 are increased in patients with graft versus host disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389013/
https://www.ncbi.nlm.nih.gov/pubmed/26000151
http://dx.doi.org/10.1007/s13317-013-0054-7
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