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Protective molecules and their cognate antibodies: new players in autoimmunity

Impairment of the clearance of apoptotic material seems to contribute to autoantigen exposure, which can initiate or maintain an autoimmune response in predisposed individuals. Complement component C1q, Creactive protein (CRP), serum amyloid P (SAP), mannose-binding lectin (MBL), apolipoprotein A-1...

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Autores principales: Zen, Margherita, Bassi, Nicola, Campana, Carla, Bettio, Silvano, Tarricone, Elena, Nalotto, Linda, Ghirardello, Anna, Doria, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389047/
https://www.ncbi.nlm.nih.gov/pubmed/26000109
http://dx.doi.org/10.1007/s13317-010-0010-8
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author Zen, Margherita
Bassi, Nicola
Campana, Carla
Bettio, Silvano
Tarricone, Elena
Nalotto, Linda
Ghirardello, Anna
Doria, Andrea
author_facet Zen, Margherita
Bassi, Nicola
Campana, Carla
Bettio, Silvano
Tarricone, Elena
Nalotto, Linda
Ghirardello, Anna
Doria, Andrea
author_sort Zen, Margherita
collection PubMed
description Impairment of the clearance of apoptotic material seems to contribute to autoantigen exposure, which can initiate or maintain an autoimmune response in predisposed individuals. Complement component C1q, Creactive protein (CRP), serum amyloid P (SAP), mannose-binding lectin (MBL), apolipoprotein A-1 (Apo A-1) and long pentraxin 3 (PTX3) are molecules involved in the removal of apoptotic bodies and pathogens, and in other antiinflammatory pathways. For this reason they have been called “protective” molecules. C1q has a key role in the activation of the complement cascade and acts as a bridging molecule between apoptotic bodies and macrophages favouring phagocytosis. In addition to other functions, CRP, SAP and MBL bind to the surface of numerous pathogens as well as cellular debris and activate the complement cascade, thus stimulating their clearance by immune cells. The role of PTX3 is more controversial. In fact, PTX also promotes the clearance of microorganisms, but the activation of the complement cascade through C1q and removal of apoptotic material can be either stimulated or inhibited by this molecule. Antibodies against protective molecules have been recently reported in systemic lupus erythematosus and other autoimmune rheumatic diseases. Some of them seem to be pathogenetic and others protective. Thus, protective molecules and their cognate antibodies may constitute a regulatory network involved in autoimmunity. Dysregulation of this system might contribute to the development of autoimmune diseases in predisposed individuals.
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spelling pubmed-43890472015-05-21 Protective molecules and their cognate antibodies: new players in autoimmunity Zen, Margherita Bassi, Nicola Campana, Carla Bettio, Silvano Tarricone, Elena Nalotto, Linda Ghirardello, Anna Doria, Andrea Auto Immun Highlights Review Article Impairment of the clearance of apoptotic material seems to contribute to autoantigen exposure, which can initiate or maintain an autoimmune response in predisposed individuals. Complement component C1q, Creactive protein (CRP), serum amyloid P (SAP), mannose-binding lectin (MBL), apolipoprotein A-1 (Apo A-1) and long pentraxin 3 (PTX3) are molecules involved in the removal of apoptotic bodies and pathogens, and in other antiinflammatory pathways. For this reason they have been called “protective” molecules. C1q has a key role in the activation of the complement cascade and acts as a bridging molecule between apoptotic bodies and macrophages favouring phagocytosis. In addition to other functions, CRP, SAP and MBL bind to the surface of numerous pathogens as well as cellular debris and activate the complement cascade, thus stimulating their clearance by immune cells. The role of PTX3 is more controversial. In fact, PTX also promotes the clearance of microorganisms, but the activation of the complement cascade through C1q and removal of apoptotic material can be either stimulated or inhibited by this molecule. Antibodies against protective molecules have been recently reported in systemic lupus erythematosus and other autoimmune rheumatic diseases. Some of them seem to be pathogenetic and others protective. Thus, protective molecules and their cognate antibodies may constitute a regulatory network involved in autoimmunity. Dysregulation of this system might contribute to the development of autoimmune diseases in predisposed individuals. Springer International Publishing 2010-11-04 /pmc/articles/PMC4389047/ /pubmed/26000109 http://dx.doi.org/10.1007/s13317-010-0010-8 Text en © Springer-Verlag 2010
spellingShingle Review Article
Zen, Margherita
Bassi, Nicola
Campana, Carla
Bettio, Silvano
Tarricone, Elena
Nalotto, Linda
Ghirardello, Anna
Doria, Andrea
Protective molecules and their cognate antibodies: new players in autoimmunity
title Protective molecules and their cognate antibodies: new players in autoimmunity
title_full Protective molecules and their cognate antibodies: new players in autoimmunity
title_fullStr Protective molecules and their cognate antibodies: new players in autoimmunity
title_full_unstemmed Protective molecules and their cognate antibodies: new players in autoimmunity
title_short Protective molecules and their cognate antibodies: new players in autoimmunity
title_sort protective molecules and their cognate antibodies: new players in autoimmunity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389047/
https://www.ncbi.nlm.nih.gov/pubmed/26000109
http://dx.doi.org/10.1007/s13317-010-0010-8
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