Overlap between dermatomyositis and ANCA vasculitides

We present the second report of the association between antineutrophil cytoplasm antibodies (ANCA)-associated vasculitis with dermatomyositis (DM). A 47-year-old woman suddenly developed rapidly progressive renal failure in the context of (DM). The kidney biopsy showed focal and segmental necrotizin...

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Autores principales: Yuste, Claudia, Rapalai, Molefe, Pritchard, Benjamin A., Jones, Terence J., Amoasii, Constanza, Al-Ansari, Atheer, Ramakrishna, Satish B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Clinical Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389158/
https://www.ncbi.nlm.nih.gov/pubmed/25859353
http://dx.doi.org/10.1093/ckj/sft142
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author Yuste, Claudia
Rapalai, Molefe
Pritchard, Benjamin A.
Jones, Terence J.
Amoasii, Constanza
Al-Ansari, Atheer
Ramakrishna, Satish B.
author_facet Yuste, Claudia
Rapalai, Molefe
Pritchard, Benjamin A.
Jones, Terence J.
Amoasii, Constanza
Al-Ansari, Atheer
Ramakrishna, Satish B.
author_sort Yuste, Claudia
collection PubMed
description We present the second report of the association between antineutrophil cytoplasm antibodies (ANCA)-associated vasculitis with dermatomyositis (DM). A 47-year-old woman suddenly developed rapidly progressive renal failure in the context of (DM). The kidney biopsy showed focal and segmental necrotizing glomerulonephritis with crescent formation. Cyclophosphamide treatment was commenced resulting in a significant recovery of kidney function and maintenance of recovery at 6 months. Although the pathophysiology is unknown, we hypothesize that CD8-T-deficient cells and MPO+ neutrophils in the DM lesions play an important role in the disease process.
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spelling pubmed-43891582015-04-09 Overlap between dermatomyositis and ANCA vasculitides Yuste, Claudia Rapalai, Molefe Pritchard, Benjamin A. Jones, Terence J. Amoasii, Constanza Al-Ansari, Atheer Ramakrishna, Satish B. Clin Kidney J Clinical Cases We present the second report of the association between antineutrophil cytoplasm antibodies (ANCA)-associated vasculitis with dermatomyositis (DM). A 47-year-old woman suddenly developed rapidly progressive renal failure in the context of (DM). The kidney biopsy showed focal and segmental necrotizing glomerulonephritis with crescent formation. Cyclophosphamide treatment was commenced resulting in a significant recovery of kidney function and maintenance of recovery at 6 months. Although the pathophysiology is unknown, we hypothesize that CD8-T-deficient cells and MPO+ neutrophils in the DM lesions play an important role in the disease process. Oxford University Press 2014-02 2013-12-23 /pmc/articles/PMC4389158/ /pubmed/25859353 http://dx.doi.org/10.1093/ckj/sft142 Text en © The Author 2013. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please email: journals.permissions@oup.com. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Clinical Cases
Yuste, Claudia
Rapalai, Molefe
Pritchard, Benjamin A.
Jones, Terence J.
Amoasii, Constanza
Al-Ansari, Atheer
Ramakrishna, Satish B.
Overlap between dermatomyositis and ANCA vasculitides
title Overlap between dermatomyositis and ANCA vasculitides
title_full Overlap between dermatomyositis and ANCA vasculitides
title_fullStr Overlap between dermatomyositis and ANCA vasculitides
title_full_unstemmed Overlap between dermatomyositis and ANCA vasculitides
title_short Overlap between dermatomyositis and ANCA vasculitides
title_sort overlap between dermatomyositis and anca vasculitides
topic Clinical Cases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389158/
https://www.ncbi.nlm.nih.gov/pubmed/25859353
http://dx.doi.org/10.1093/ckj/sft142
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