Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine

Aberrant activation of NF-κB is associated with the development of cancer and autoimmune and inflammatory diseases. IKKs are well recognized as key regulators in the NF-κB pathway and therefore represent attractive targets for intervention with small molecule inhibitors. Herein, we report that a com...

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Detalles Bibliográficos
Autores principales: Dong, Ting, Li, Chao, Wang, Xing, Dian, Longyang, Zhang, Xiuguo, Li, Lin, Chen, She, Cao, Ran, Li, Li, Huang, Niu, He, Sudan, Lei, Xiaoguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389228/
https://www.ncbi.nlm.nih.gov/pubmed/25813672
http://dx.doi.org/10.1038/ncomms7522

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