Genome-wide profiling of p53-regulated enhancer RNAs uncovers a subset of enhancers controlled by a lncRNA

p53 binds enhancers to regulate key target genes. Here, we globally mapped p53-regulated enhancers by looking at enhancer RNA (eRNA) production. Intriguingly, while many p53-induced enhancers contained p53-binding sites, most did not. As long non-coding RNAs (lncRNAs) are prominent regulators of chr...

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Detalles Bibliográficos
Autores principales: Léveillé, Nicolas, Melo, Carlos A., Rooijers, Koos, Díaz-Lagares, Angel, Melo, Sonia A., Korkmaz, Gozde, Lopes, Rui, Moqadam, Farhad Akbari, Maia, Ana R., Wijchers, Patrick J., Geeven, Geert, den Boer, Monique L., Kalluri, Raghu, de Laat, Wouter, Esteller, Manel, Agami, Reuven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389233/
https://www.ncbi.nlm.nih.gov/pubmed/25813522
http://dx.doi.org/10.1038/ncomms7520

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