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Quantification and Localization of Mast Cells in Periapical Lesions

BACKGROUND: Periapical lesions occur in response to chronic irritation in periapical tissue, generally resulting from an infected root canal. Specific etiological agents of induction, participating cell population and growth factors associated with maintenance and resolution of periapical lesions ar...

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Autores principales: Mahita, VN, Manjunatha, BS, Shah, R, Astekar, M, Purohit, S, Kovvuru, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389325/
https://www.ncbi.nlm.nih.gov/pubmed/25861530
http://dx.doi.org/10.4103/2141-9248.153616
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author Mahita, VN
Manjunatha, BS
Shah, R
Astekar, M
Purohit, S
Kovvuru, S
author_facet Mahita, VN
Manjunatha, BS
Shah, R
Astekar, M
Purohit, S
Kovvuru, S
author_sort Mahita, VN
collection PubMed
description BACKGROUND: Periapical lesions occur in response to chronic irritation in periapical tissue, generally resulting from an infected root canal. Specific etiological agents of induction, participating cell population and growth factors associated with maintenance and resolution of periapical lesions are incompletely understood. Among the cells found in periapical lesions, mast cells have been implicated in the inflammatory mechanism. AIM: Quantifications and the possible role played by mast cells in the periapical granuloma and radicular cyst. Hence, this study is to emphasize the presence (localization) and quantification of mast cells in periapical granuloma and radicular cyst. MATERIALS AND METHODS: A total of 30 cases and out of which 15 of periapical granuloma and 15 radicular cyst, each along with the case details from the previously diagnosed cases in the department of oral pathology were selected for the study. The gender distribution showed male 8 (53.3%) and females 7 (46.7%) in periapical granuloma cases and male 10 (66.7%) and females 5 (33.3%) in radicular cyst cases. The statistical analysis used was unpaired t-test. RESULTS: Mean mast cell count in periapical granuloma subepithelial and deeper connective tissue, was 12.40 (0.99%) and 7.13 (0.83%), respectively. The mean mast cell counts in subepithelial and deeper connective tissue of radicular cyst were 17.64 (1.59%) and 12.06 (1.33%) respectively, which was statistically significant. No statistical significant difference was noted among males and females. CONCLUSION: Mast cells were more in number in radicular cyst. Based on the concept that mast cells play a critical role in the induction of inflammation, it is logical to use therapeutic agents to alter mast cell function and secretion, to thwart inflammation at its earliest phases. These findings may suggest the possible role of mast cells in the pathogenesis of periapical lesions.
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spelling pubmed-43893252015-04-08 Quantification and Localization of Mast Cells in Periapical Lesions Mahita, VN Manjunatha, BS Shah, R Astekar, M Purohit, S Kovvuru, S Ann Med Health Sci Res Original Article BACKGROUND: Periapical lesions occur in response to chronic irritation in periapical tissue, generally resulting from an infected root canal. Specific etiological agents of induction, participating cell population and growth factors associated with maintenance and resolution of periapical lesions are incompletely understood. Among the cells found in periapical lesions, mast cells have been implicated in the inflammatory mechanism. AIM: Quantifications and the possible role played by mast cells in the periapical granuloma and radicular cyst. Hence, this study is to emphasize the presence (localization) and quantification of mast cells in periapical granuloma and radicular cyst. MATERIALS AND METHODS: A total of 30 cases and out of which 15 of periapical granuloma and 15 radicular cyst, each along with the case details from the previously diagnosed cases in the department of oral pathology were selected for the study. The gender distribution showed male 8 (53.3%) and females 7 (46.7%) in periapical granuloma cases and male 10 (66.7%) and females 5 (33.3%) in radicular cyst cases. The statistical analysis used was unpaired t-test. RESULTS: Mean mast cell count in periapical granuloma subepithelial and deeper connective tissue, was 12.40 (0.99%) and 7.13 (0.83%), respectively. The mean mast cell counts in subepithelial and deeper connective tissue of radicular cyst were 17.64 (1.59%) and 12.06 (1.33%) respectively, which was statistically significant. No statistical significant difference was noted among males and females. CONCLUSION: Mast cells were more in number in radicular cyst. Based on the concept that mast cells play a critical role in the induction of inflammation, it is logical to use therapeutic agents to alter mast cell function and secretion, to thwart inflammation at its earliest phases. These findings may suggest the possible role of mast cells in the pathogenesis of periapical lesions. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4389325/ /pubmed/25861530 http://dx.doi.org/10.4103/2141-9248.153616 Text en Copyright: © Annals of Medical and Health Sciences Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mahita, VN
Manjunatha, BS
Shah, R
Astekar, M
Purohit, S
Kovvuru, S
Quantification and Localization of Mast Cells in Periapical Lesions
title Quantification and Localization of Mast Cells in Periapical Lesions
title_full Quantification and Localization of Mast Cells in Periapical Lesions
title_fullStr Quantification and Localization of Mast Cells in Periapical Lesions
title_full_unstemmed Quantification and Localization of Mast Cells in Periapical Lesions
title_short Quantification and Localization of Mast Cells in Periapical Lesions
title_sort quantification and localization of mast cells in periapical lesions
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389325/
https://www.ncbi.nlm.nih.gov/pubmed/25861530
http://dx.doi.org/10.4103/2141-9248.153616
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