The calcium paradox - What should we have to fear?

The calcium paradox was first mentioned in 1966 by Zimmerman et al. Thereafter gained great interest from the scientific community due to the fact of the absence of calcium ions in heart muscle cells produce damage similar to ischemia-reperfusion. Although not all known mechanisms involved in cellul...

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Detalles Bibliográficos
Autores principales: de Oliveira, Marcos Aurélio Barboza, Brandi, Antônio Carlos, dos Santos, Carlos Alberto, Botelho, Paulo Henrique Husseni, Cortez, José Luís Lasso, Goissis, Gilberto, Braile, Domingo Marcolino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Cirurgia Cardiovascular 2014
Materias:
Special Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389471/
https://www.ncbi.nlm.nih.gov/pubmed/25140476
http://dx.doi.org/10.5935/1678-9741.20140054
Descripción
Sumario:The calcium paradox was first mentioned in 1966 by Zimmerman et al. Thereafter gained great interest from the scientific community due to the fact of the absence of calcium ions in heart muscle cells produce damage similar to ischemia-reperfusion. Although not all known mechanisms involved in cellular injury in the calcium paradox intercellular connection maintained only by nexus seems to have a key role in cellular fragmentation. The addition of small concentrations of calcium, calcium channel blockers, and hyponatraemia hypothermia are important to prevent any cellular damage during reperfusion solutions with physiological concentration of calcium.

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