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Determinants of peak VO(2) in heart transplant recipients

OBJECTIVE: To establish the determinants of the peak VO(2) in heart transplant recipients. METHODS: Patient's assessment was performed in two consecutive days. In the first day, patients performed the heart rate variability assessment followed by a cardiopulmonary exercise test. In the second d...

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Autores principales: Carvalho, Vitor Oliveira, Guimarães, Guilherme Veiga, Campos-Vieira, Marcelo Luiz, Catai, Aparecida Maria, Oliveira-Carvalho, Vagner, Ayub-Ferreira, Silvia Moreira, Bocchi, Edimar Alcides
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Cirurgia Cardiovascular 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389529/
https://www.ncbi.nlm.nih.gov/pubmed/25859862
http://dx.doi.org/10.5935/1678-9741.20140055
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author Carvalho, Vitor Oliveira
Guimarães, Guilherme Veiga
Campos-Vieira, Marcelo Luiz
Catai, Aparecida Maria
Oliveira-Carvalho, Vagner
Ayub-Ferreira, Silvia Moreira
Bocchi, Edimar Alcides
author_facet Carvalho, Vitor Oliveira
Guimarães, Guilherme Veiga
Campos-Vieira, Marcelo Luiz
Catai, Aparecida Maria
Oliveira-Carvalho, Vagner
Ayub-Ferreira, Silvia Moreira
Bocchi, Edimar Alcides
author_sort Carvalho, Vitor Oliveira
collection PubMed
description OBJECTIVE: To establish the determinants of the peak VO(2) in heart transplant recipients. METHODS: Patient's assessment was performed in two consecutive days. In the first day, patients performed the heart rate variability assessment followed by a cardiopulmonary exercise test. In the second day, patients performed a resting echocardiography. Heart transplant recipients were eligible if they were in a stable condition and without any evidence of tissue rejection diagnosed by endomyocardial biopsy. Patients with pacemaker, noncardiovascular functional limitations such as osteoarthritis and chronic obstructive pulmonary disease were excluded from this study. RESULTS: Sixty patients (68% male, 48 years and 64 months following heart transplantation) were assessed. Multivariate analysis selected the following variables: receptor's gender (P =0.001), receptor age (P =0.049), receptor Body Mass Index (P =0.005), heart rate reserve (P <0.0001), left atrium diameter (P =0.016). Multivariate analysis showed r=0.77 and r2=0.6 with P <0.001. Equation: peakVO(2) =32.851 - 3.708 (receptor gender) - 0.067 (receptor age) - 0.318 (receptor BMI) + 0.145 (heart rate reserve) - 0.111 (left atrium diameter). CONCLUSION: The determinants of the peak VO(2) in heart transplant recipients were: receptor sex, age, Body Mass Index, heart rate reserve and left atrium diameter. Heart rate reserve was the unique variable positively associated with peak VO(2) . This data suggest the importance of the sympathetic reinnervation in peak VO(2) in heart transplant recipients.
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spelling pubmed-43895292015-04-14 Determinants of peak VO(2) in heart transplant recipients Carvalho, Vitor Oliveira Guimarães, Guilherme Veiga Campos-Vieira, Marcelo Luiz Catai, Aparecida Maria Oliveira-Carvalho, Vagner Ayub-Ferreira, Silvia Moreira Bocchi, Edimar Alcides Rev Bras Cir Cardiovasc Original Articles OBJECTIVE: To establish the determinants of the peak VO(2) in heart transplant recipients. METHODS: Patient's assessment was performed in two consecutive days. In the first day, patients performed the heart rate variability assessment followed by a cardiopulmonary exercise test. In the second day, patients performed a resting echocardiography. Heart transplant recipients were eligible if they were in a stable condition and without any evidence of tissue rejection diagnosed by endomyocardial biopsy. Patients with pacemaker, noncardiovascular functional limitations such as osteoarthritis and chronic obstructive pulmonary disease were excluded from this study. RESULTS: Sixty patients (68% male, 48 years and 64 months following heart transplantation) were assessed. Multivariate analysis selected the following variables: receptor's gender (P =0.001), receptor age (P =0.049), receptor Body Mass Index (P =0.005), heart rate reserve (P <0.0001), left atrium diameter (P =0.016). Multivariate analysis showed r=0.77 and r2=0.6 with P <0.001. Equation: peakVO(2) =32.851 - 3.708 (receptor gender) - 0.067 (receptor age) - 0.318 (receptor BMI) + 0.145 (heart rate reserve) - 0.111 (left atrium diameter). CONCLUSION: The determinants of the peak VO(2) in heart transplant recipients were: receptor sex, age, Body Mass Index, heart rate reserve and left atrium diameter. Heart rate reserve was the unique variable positively associated with peak VO(2) . This data suggest the importance of the sympathetic reinnervation in peak VO(2) in heart transplant recipients. Sociedade Brasileira de Cirurgia Cardiovascular 2015 /pmc/articles/PMC4389529/ /pubmed/25859862 http://dx.doi.org/10.5935/1678-9741.20140055 Text en http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Carvalho, Vitor Oliveira
Guimarães, Guilherme Veiga
Campos-Vieira, Marcelo Luiz
Catai, Aparecida Maria
Oliveira-Carvalho, Vagner
Ayub-Ferreira, Silvia Moreira
Bocchi, Edimar Alcides
Determinants of peak VO(2) in heart transplant recipients
title Determinants of peak VO(2) in heart transplant recipients
title_full Determinants of peak VO(2) in heart transplant recipients
title_fullStr Determinants of peak VO(2) in heart transplant recipients
title_full_unstemmed Determinants of peak VO(2) in heart transplant recipients
title_short Determinants of peak VO(2) in heart transplant recipients
title_sort determinants of peak vo(2) in heart transplant recipients
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389529/
https://www.ncbi.nlm.nih.gov/pubmed/25859862
http://dx.doi.org/10.5935/1678-9741.20140055
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