Equilibrated Atomic Models of Outward-Facing P-glycoprotein and Effect of ATP Binding on Structural Dynamics

P-glycoprotein (Pgp) is an ATP-binding cassette (ABC) transporter that alternates between inward- and outward-facing conformations to capture and force substrates out of cells like a peristaltic pump. The high degree of similarity in outward-facing structures across evolution of ABC transporters all...

Descripción completa

Detalles Bibliográficos
Autores principales: Pan, Lurong, Aller, Stephen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389535/
https://www.ncbi.nlm.nih.gov/pubmed/25600711
http://dx.doi.org/10.1038/srep07880

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389535/
https://www.ncbi.nlm.nih.gov/pubmed/25600711
http://dx.doi.org/10.1038/srep07880

Ejemplares similares