Changing the topology of protein backbone: the effect of backbone cyclization on the structure and dynamics of a SH3 domain

Understanding of the effects of the backbone cyclization on the structure and dynamics of a protein is essential for using protein topology engineering to alter protein stability and function. Here we have determined, for the first time, the structure and dynamics of the linear and various circular...

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Detalles Bibliográficos
Autores principales: Schumann, Frank H., Varadan, Ranjani, Tayakuniyil, Praveen P., Grossman, Jennifer H., Camarero, Julio A., Fushman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389572/
https://www.ncbi.nlm.nih.gov/pubmed/25905098
http://dx.doi.org/10.3389/fchem.2015.00026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389572/
https://www.ncbi.nlm.nih.gov/pubmed/25905098
http://dx.doi.org/10.3389/fchem.2015.00026

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